Search
Descriptor English: Cytochrome P-450 Enzyme System
Descriptor Spanish: Sistema Enzimático del Citocromo P-450
Descriptor sistema enzimático del citocromo P-450
Entry term(s) citocromo P-450
enzima P-450
enzima P450
enzima del citocromo P-450
monooxigenasa dependiente del citocromo P-450
sistema enzimático del citocromo P450
Scope note: Superfamilia de cientos de HEMOPROTEÍNAS muy relacionadas que se encuentran en todo el espectro filogenético: animales, plantas, hongos y bacterias. Incluyen numerosos complejos de monooxigenasas (OXIGENASAS DE FUNCIÓN MIXTA). En los animales, estas enzimas P-450 tienen dos funciones: (1) biosíntesis de esteroides, ácidos grasos y ácidos biliares; (2) metabolismo de sustratos endógenos y una gran variedad de sustratos exógenos, como toxinas y fármacos (BIOTRANSFORMACIÓN). Se clasifican de acuerdo con la semejanza de secuencia, más que por las funciones, en familias (más que 40 por ciento de homología) y subfamilias (más que 59 por ciento de homología) del gen CYP. Por ejemplo, las enzimas de las familias CYP1, CYP2 y CYP3 son responsables de la mayor parte del metabolismo de los fármacos.
Descriptor Portuguese: Sistema Enzimático do Citocromo P-450
Descriptor French: Cytochrome P-450 enzyme system
Entry term(s): Cytochrome P-450 monooxygenase
Cytochrome P-450 oxygenase
Système cytochrome P450
Système enzymatique du cytochrome P-450
Tree number(s): D08.244.453
D08.811.682.690.708.170
D12.776.422.220.453
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003577
Scope note: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Annotation: general or unspecified; prefer specific cytochrome P-450's
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Cytochrome P-450 Enzyme Inhibitors
Registry Number: 9035-51-2
CAS Type 1 Name: Cytochrome P 450
DeCS ID: 3595
Unique ID: D003577
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27
Cytochrome P-450 enzyme system - Preferred
Concept UI M0005591
Preferred term Cytochrome P-450 enzyme system
Entry term(s) Système cytochrome P450
Système enzymatique du cytochrome P-450
Cytochrome P-450 monooxygenase - Narrower
Concept UI M0005593
Preferred term Cytochrome P-450 monooxygenase
Cytochrome P-450 oxygenase - Narrower
Concept UI M0005592
Preferred term Cytochrome P-450 oxygenase



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.

Go to survey