| Descriptor English: | Aryl Hydrocarbon Hydroxylases | ||||||
| Descriptor Spanish: |
Hidrocarburo de Aril Hidroxilasas
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| Descriptor Portuguese: | Hidrocarboneto de Aril Hidroxilases | ||||||
| Descriptor French: | Aryl hydrocarbon hydroxylases | ||||||
| Entry term(s): |
Hydroxylases, Aryl Hydrocarbon Microsomal Monooxygenases Monooxygenases, Microsomal Monooxygenases, Xenobiotic Xenobiotic Monooxygenases |
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| Tree number(s): |
D08.244.453.005 D08.811.682.690.708.170.010 D12.776.422.220.453.010 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D001189 | ||||||
| Scope note: | A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 1.14.14.1 | ||||||
| Previous Indexing: |
Hydroxylases (1971-1974) Polycyclic Hydrocarbons (1974) |
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| Public MeSH Note: | 75 |
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| History Note: | 75 |
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| DeCS ID: | 23163 | ||||||
| Unique ID: | D001189 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1975/09/01 | ||||||
| Date of Entry: | 1974/11/11 | ||||||
| Revision Date: | 2016/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Aryl Hydrocarbon Hydroxylases
- Preferred
Xenobiotic Monooxygenases
- Narrower
| Concept UI |
M0001774 |
| Scope note | A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides. |
| Preferred term | Aryl Hydrocarbon Hydroxylases |
| Entry term(s) |
Hydroxylases, Aryl Hydrocarbon Microsomal Monooxygenases Monooxygenases, Microsomal |
| Concept UI |
M0417290 |
| Scope note | Monooxygenases that oxidize exogenous substrates. |
| Preferred term | Xenobiotic Monooxygenases |
| Entry term(s) |
Monooxygenases, Xenobiotic |
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