| Descriptor English: | Cytochrome P-450 CYP3A | ||||||
| Descriptor Spanish: |
Citocromo P-450 CYP3A
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| Descriptor Portuguese: | Citocromo P-450 CYP3A | ||||||
| Descriptor French: | Cytochrome P-450 CYP3A | ||||||
| Entry term(s): |
3A5, Cytochrome P450 6-alpha-Monooxygenase, Taurochenodeoxycholate CYP3A CYP3A4 CYP3A5 Cytochrome P 450 CYP3A Cytochrome P 450 CYP3A4 Cytochrome P 450 CYP3A5 Cytochrome P 450IIIA Cytochrome P-450 CYP3A4 Cytochrome P-450 CYP3A5 Cytochrome P-450IIIA Cytochrome P450 3A Cytochrome P450 3A4 Cytochrome P450 3A5 Erythromycin N Demethylase Erythromycin N-Demethylase N-Demethylase, Erythromycin P-450 CYP3A, Cytochrome P-450 CYP3A4, Cytochrome P-450 CYP3A5, Cytochrome P-450IIIA, Cytochrome P450 3A, Cytochrome P450 3A5, Cytochrome Taurochenodeoxycholate 6 alpha Monooxygenase Taurochenodeoxycholate 6-alpha-Monooxygenase |
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| Tree number(s): |
D08.244.453.860.500 D08.811.682.662.582.353 D08.811.682.690.708.170.495.500 D12.776.422.220.453.860.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D051544 | ||||||
| Scope note: | A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
antagonists & inhibitors:Cytochrome P-450 CYP3A Inhibitors
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| Registry Number: | EC 1.14.14.1 | ||||||
| Public MeSH Note: | 2006; CYTOCHROME P-450 CYP3A was indexed under ARYL HYDROCARBON HYDROXYLASES & OXIDOREDUCTASES, N-DEMETHYLATING 1980-2005 |
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| History Note: | 2006(1980) |
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| DeCS ID: | 50572 | ||||||
| Unique ID: | D051544 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2016/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Cytochrome P-450 CYP3A
- Preferred
Cytochrome P-450 CYP3A5
- Narrower
Cytochrome P-450 CYP3A4
- Narrower
| Concept UI |
M0082919 |
| Scope note | A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN. |
| Preferred term | Cytochrome P-450 CYP3A |
| Entry term(s) |
CYP3A Cytochrome P 450 CYP3A Cytochrome P 450IIIA Cytochrome P-450IIIA Cytochrome P450 3A Erythromycin N Demethylase Erythromycin N-Demethylase N-Demethylase, Erythromycin P-450 CYP3A, Cytochrome P-450IIIA, Cytochrome P450 3A, Cytochrome |
| Concept UI |
M0591310 |
| Scope note | A specific subtype of CYP3A. |
| Preferred term | Cytochrome P-450 CYP3A5 |
| Entry term(s) |
3A5, Cytochrome P450 CYP3A5 Cytochrome P 450 CYP3A5 Cytochrome P450 3A5 P-450 CYP3A5, Cytochrome P450 3A5, Cytochrome |
| Concept UI |
M0591309 |
| Scope note | A specific subtype of CYP3A. |
| Preferred term | Cytochrome P-450 CYP3A4 |
| Entry term(s) |
6-alpha-Monooxygenase, Taurochenodeoxycholate CYP3A4 Cytochrome P 450 CYP3A4 Cytochrome P450 3A4 P-450 CYP3A4, Cytochrome Taurochenodeoxycholate 6 alpha Monooxygenase Taurochenodeoxycholate 6-alpha-Monooxygenase |
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