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Descriptor English: Cytochrome P-450 CYP2E1
Descriptor Spanish: Citocromo P-450 CYP2E1
Descriptor citocromo P-450 CYP2E1
Entry term(s) 4-nitrofenol-2-hidroxilasa
CYP2E1
citocromo P450 CYP2E1
dimetilnitrosamina N-desmetilasa
Scope note: Enzima del citocromo P450 que puede ser inducida por el etanol y que metaboliza distintos precarcinógenos, fármacos y solventes, lo que da lugar a metabolitos reactivos. Entre sus substratos se encuentran el ETANOL, ANESTÉSICOS POR INHALACIÓN, PARACETAMOL y otros compuestos de bajo peso molecular. Se ha utilizado la CYP2E1 como marcador enzimático en el estudio del abuso del alcohol.
Descriptor Portuguese: Citocromo P-450 CYP2E1
Descriptor French: Cytochrome P-450 CYP2E1
Entry term(s): 4 Nitrophenol 2 Hydroxylase
4-Nitrophenol-2-Hydroxylase
CYP 2E1
CYP IIE1
CYP2E1
CYPIIE1
Cytochrome P 450 CYP2E1
Cytochrome P 450 IIE1
Cytochrome P 450 J
Cytochrome P-450 (ALC)
Cytochrome P-450 IIE1
Cytochrome P-450-J
Cytochrome P450 2E1
Dimethylnitrosamine N Demethylase
Dimethylnitrosamine N-Demethylase
N Nitrosodimethylamine Demethylase
N-Nitrosodimethylamine Demethylase
Tree number(s): D08.244.453.491.375
D08.811.682.662.582.338
D08.811.682.690.708.170.450.375
D12.776.422.220.453.491.375
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019392
Scope note: An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Annotation: do not confuse with other cytochrome P-450 CYP's
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Cytochrome P-450 CYP2E1 Inhibitors
Registry Number: EC 1.14.13.-
Previous Indexing: Cytochrome P-450 (1975-1996)
Hydroxylases (1984-1996)
Nitrosamines (1972-1976)
Oxidoreductases (1972-1974)
Oxidoreductases, N-Demethylating (1975-1996)
Public MeSH Note: 97; DIMETHYLNITROSAMINE N-DEMETHYLASE was indexed under CYTOCHROME P-450 & OXIDOREDUCTASES, N-DEMETHYLATING 1975-96, NITROSAMINES 1972-76, & OXIDOREDUCTASES 1972-74; 4-NITROPHENOL-2-HYDROXYLASE was indexed under CYTOCHROME P-450 & HYDROXYLASES 1984-96
Online Note: use CYTOCHROME P-450 CYP2E1 (NM) to search DIMETHYLNITROSAMINE N-DEMETHYLASE 1980-96 & 4-NITROPHENOL-2-HYDROXYLASE 1984-96
History Note: 97; was DIMETHYLNITROSAMIME N-DEMETHYLASE (NM) 1972-96 & was 4-NITROPHENOL-2-HYDROXYLASE (NM) 1984-96
DeCS ID: 33012
Unique ID: D019392
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1997/01/01
Date of Entry: 1996/06/24
Revision Date: 2016/05/27
Cytochrome P-450 CYP2E1 - Preferred
Concept UI M0028857
Scope note An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.
Preferred term Cytochrome P-450 CYP2E1
Entry term(s) 4 Nitrophenol 2 Hydroxylase
4-Nitrophenol-2-Hydroxylase
CYP 2E1
CYP IIE1
CYP2E1
CYPIIE1
Cytochrome P 450 CYP2E1
Cytochrome P 450 IIE1
Cytochrome P 450 J
Cytochrome P-450 (ALC)
Cytochrome P-450 IIE1
Cytochrome P-450-J
Cytochrome P450 2E1
Dimethylnitrosamine N Demethylase
Dimethylnitrosamine N-Demethylase
N Nitrosodimethylamine Demethylase
N-Nitrosodimethylamine Demethylase



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