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Descriptor English: AlkB Homolog 4, Lysine Demethylase
Descriptor Spanish: Homólogo 4 de AlkB Lisina Desmetilasa
Descriptor homólogo 4 de AlkB lisina desmetilasa
Entry term(s) homólogo 4 de Alkb dioxigenasa dependiente de alfacetoglutarato
proteína homólogo 4 de AlkB reparadora de ADN alquilado
Scope note: Dioxigenasa y homólogo de la reparación de los daños por alquilación que media en la desmetilación en ´Lys-84´ (K84me1). La desmetilación de la LISINA 84 (K84me1) de la actina es necesaria para mantener la dinámica de la actina y la MIOSINA para la penetración normal del surco de escisión durante la CITOCINESIS y para la MIGRACIÓN CELULAR. También puede participar en la regulación de la transcripción.
Descriptor Portuguese: Homólogo AlkB 4 da Lisina Desmetilase
Descriptor French: AlkB Homolog 4, lysine demethylase
Entry term(s): Alkylated DNA Repair Protein AlkB Homolog 4
Alpha Ketoglutarate Dependent Dioxygenase Alkb Homolog 4
Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4
Tree number(s): D08.811.682.662.582.138
D08.811.682.690.416.139.937
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071501
Scope note: A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.11.27
Previous Indexing: Dioxygenases (2014-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56501
Unique ID: D000071501
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/07/01
AlkB Homolog 4, Lysine Demethylase - Preferred
Concept UI M000614943
Scope note A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation.
Preferred term AlkB Homolog 4, Lysine Demethylase
Entry term(s) Alkylated DNA Repair Protein AlkB Homolog 4
Alpha Ketoglutarate Dependent Dioxygenase Alkb Homolog 4
Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4



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