DeCS

Descriptor English:

Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Descriptor Spanish:

Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato

Spanish from Spain

Descriptor	dioxigenasa FTO dependiente de alfa-cetoglutarato
Entry term(s)	dioxigenasa dependiente de alfa-cetoglutarato homólogo 9 de la proteína AlkB proteína asociada a masa de grasa y obesidad proteína asociada a masa de grasa y obesidad (FTO)
Scope note:	Dioxigenasa que repara ADN y ARN alquilados mediante desmetilación oxidativa. Tiene mayor actividad sobre el ARN de cadena simple que contiene 3-metiluracilo, seguido del ADN DE CADENA SIMPLE que contiene 3-metiltimina y desmetila de forma específica la N(6)-metiladenosina del ARN, que es la modificación interna más frecuente del ARN MENSAJERO (ARNm) en EUCARIOTAS superiores. Contribuye en la regulación del metabolismo global, la HOMEOSTASIS energética y el depósito corporal de grasa mediante la regulación de la diferenciación de ADIPOCITOS hacia células del TEJIDO ADIPOSO PARDO o del TEJIDO ADIPOSO BLANCO.

Descriptor Portuguese:

Dioxigenase FTO Dependente de alfa-Cetoglutarato

Descriptor French:

Alpha-ketoglutarate-dependent dioxygenase FTO

Entry term(s):

AlkB Homolog 9 Protein
Alpha Ketoglutarate Dependent Dioxygenase
Alpha Ketoglutarate Dependent Dioxygenase FTO
Alpha-Ketoglutarate-Dependent Dioxygenase
Dioxygenase, Alpha-Ketoglutarate-Dependent
FTO, Alpha-Ketoglutarate-Dependent Dioxygenase
Fat Mass and Obesity Associated (FTO) Protein
Fat Mass and Obesity Associated Protein

Tree number(s):

D08.811.074.062.968
D08.811.682.662.582.242
D08.811.682.690.416.139.992

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000071516

Scope note:

A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Concept UI	M000614982
Scope note	A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
Preferred term	Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Entry term(s)	AlkB Homolog 9 Protein Alpha Ketoglutarate Dependent Dioxygenase Alpha Ketoglutarate Dependent Dioxygenase FTO Alpha-Ketoglutarate-Dependent Dioxygenase Dioxygenase, Alpha-Ketoglutarate-Dependent FTO, Alpha-Ketoglutarate-Dependent Dioxygenase Fat Mass and Obesity Associated (FTO) Protein Fat Mass and Obesity Associated Protein

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