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Descriptor English: AlkB Homolog 5, RNA Demethylase
Descriptor Spanish: Desmetilasa de ARN, Homólogo 5 de AlkB
Descriptor desmetilasa de ARN, homólogo 5 de AlkB
Entry term(s) desmetilasa de ARN ALKBH5
homólogo 5 de AlkB dioxigenasa dependiente de alfa-cetoglutarato
homólogo 5 de la proteína AlkB de reparación del ADN alquilado
Scope note: Una dioxigenasa y homólogo de reparación de los daños por alquilación que desmetila el ARN mediante desmetilación oxidativa. Desmetila de forma específica la N(6)-metiladenosina (m6A) del ARN, que es la modificación interna más frecuente del ARN MENSAJERO en eucariotas superiores. También puede desmetilar N(6)-metiladenosina en el ADN DE CADENA SIMPLE.
Descriptor Portuguese: Homólogo AlkB 5 da RNA Desmetilase
Descriptor French: AlkB Homolog 5, RNA demethylase
Entry term(s): ALKBH5, RNA Demethylase
Alkylated DNA Repair Protein AlkB Homolog 5
Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 5
Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 5
Demethylase ALKBH5, RNA
RNA Demethylase ALKBH5
Tree number(s): D08.811.074.062.937
D08.811.682.662.582.207
D08.811.682.690.416.139.968
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071502
Scope note: A dioxygenase and alkylation repair homolog that demethylates RNA by oxidative demethylation. It specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA in higher eukaryotes. It can also demethylate N(6)-methyladenosine in SINGLE-STRANDED DNA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.11.-
Previous Indexing: Dioxygenases (2011-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56462
Unique ID: D000071502
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/04/15
AlkB Homolog 5, RNA Demethylase - Preferred
Concept UI M000614944
Scope note A dioxygenase and alkylation repair homolog that demethylates RNA by oxidative demethylation. It specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA in higher eukaryotes. It can also demethylate N(6)-methyladenosine in SINGLE-STRANDED DNA.
Preferred term AlkB Homolog 5, RNA Demethylase
Entry term(s) ALKBH5, RNA Demethylase
Alkylated DNA Repair Protein AlkB Homolog 5
Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 5
Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 5
Demethylase ALKBH5, RNA
RNA Demethylase ALKBH5



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