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Descriptor English: AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
Descriptor Spanish: Dioxigenasa Dependiente de Alfa-Cetoglutarato, Homólogo 2 de AlkB
Descriptor dioxigenasa dependiente de alfa-cetoglutarato, homólogo 2 de AlkB
Entry term(s) desmetilasa oxidativa de ADN ALKBH2
homólogo 2 de AlkB dioxigenasa dependiente de alfa-cetoglutarato
homólogo 2 de la proteína AlkB de reparación del ADN alquilado
proteína oxi DC1
Scope note: Una dioxigenasa y homólogo de reparación de los daños por alquilación que repara ADN y ARN alquilados que contienen 1-metiladenina y 3-metilcitosina mediante desmetilación oxidativa. También repara in vitro ADN alquilado que contiene 1-etenoadenina. Tiene mayor afinidad por el ADN de cadena doble.
Descriptor Portuguese: Homólogo AlkB 2 da Dioxigenase Dependente de alfa-Cetoglutarato
Descriptor French: AlkB Homolog 2, alpha-ketoglutarate-dependent dioxygenase
Entry term(s): AlkB Homolog 2, Alpha Ketoglutarate Dependent Dioxygenase
Alkylated DNA Repair Protein AlkB Homolog 2
Alpha ketoglutarate Dependent Dioxygenase AlkB Homolog 2
Alpha-ketoglutarate-Dependent Dioxygenase AlkB Homolog 2
DNA Oxidative Demethylase ALKBH2
Oxy DC1 Protein
Tree number(s): D08.811.074.062.750
D08.811.682.690.416.139.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071499
Scope note: A dioxygenase and alkylation repair homolog that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. It can also repair alkylated DNA containing 1-ethenoadenine in vitro. It has highest affinity for double-stranded DNA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.11.33
Previous Indexing: DNA Repair Enzymes (2004-2016)
Dioxygenases (2004-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56460
Unique ID: D000071499
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/04/15
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase - Preferred
Concept UI M000614941
Scope note A dioxygenase and alkylation repair homolog that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. It can also repair alkylated DNA containing 1-ethenoadenine in vitro. It has highest affinity for double-stranded DNA.
Preferred term AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
Entry term(s) AlkB Homolog 2, Alpha Ketoglutarate Dependent Dioxygenase
Alkylated DNA Repair Protein AlkB Homolog 2
Alpha ketoglutarate Dependent Dioxygenase AlkB Homolog 2
Alpha-ketoglutarate-Dependent Dioxygenase AlkB Homolog 2
DNA Oxidative Demethylase ALKBH2
Oxy DC1 Protein



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