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Descriptor English: AlkB Homolog 1, Histone H2a Dioxygenase
Descriptor Spanish: Histona H2a Dioxigenasa, Homólogo 1 de AlkB
Descriptor histona H2a dioxigenasa, homólogo 1 de AlkB
Entry term(s) ADN liasa ABH1
desmetilasa oxidativa de ADN ALKBH1
dioxigenasa ABH1 dependiente de alfa-cetoglutarato
homólogo 1 de la proteína AlkB de reparación del ADN alquilado
proteína ALKBH
Scope note: Una dioxigenasa y homólogo de reparación de los daños por alquilación que actúa mediante la desmetilación oxidativa en la REPARACIÓN de ARN y ADN de sustratos que contienen 3-metilcitosina. También es una de las DESMETILASAS de HISTONAS implicadas en el desarrollo embrionario y que mantienen la pluripotencialidad de las CÉLULAS MADRE EMBRIONARIAS.
Descriptor Portuguese: Homólogo AlkB 1 da Histona H2a Dioxigenase
Descriptor French: AlkB Homolog 1, histone H2a dioxygenase
Entry term(s): ABH1, Alpha-Ketoglutarate-Dependent Dioxygenase
ABH1, DNA Lyase
ALKBH Protein
Alkylated DNA Repair Protein AlkB Homolog 1
Alpha Ketoglutarate Dependent Dioxygenase ABH1
Alpha-Ketoglutarate-Dependent Dioxygenase ABH1
DNA Lyase ABH1
DNA Oxidative Demethylase ALKBH1
Tree number(s): D08.811.074.062.500
D08.811.682.690.416.139.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071498
Scope note: A dioxygenase and alkylation repair homolog that functions by oxidative demethylation in RNA and DNA REPAIR of substrates which contain 3-methylcytosine. It also functions as one of the HISTONE DEMETHYLASES involved in embryonic development and maintaining the pluripotency of EMBRYONIC STEM CELLS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.11.33
Previous Indexing: DNA Repair Enzymes (2005-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56459
Unique ID: D000071498
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/04/15
AlkB Homolog 1, Histone H2a Dioxygenase - Preferred
Concept UI M000614940
Scope note A dioxygenase and alkylation repair homolog that functions by oxidative demethylation in RNA and DNA REPAIR of substrates which contain 3-methylcytosine. It also functions as one of the HISTONE DEMETHYLASES involved in embryonic development and maintaining the pluripotency of EMBRYONIC STEM CELLS.
Preferred term AlkB Homolog 1, Histone H2a Dioxygenase
Entry term(s) ABH1, Alpha-Ketoglutarate-Dependent Dioxygenase
ABH1, DNA Lyase
ALKBH Protein
Alkylated DNA Repair Protein AlkB Homolog 1
Alpha Ketoglutarate Dependent Dioxygenase ABH1
Alpha-Ketoglutarate-Dependent Dioxygenase ABH1
DNA Lyase ABH1
DNA Oxidative Demethylase ALKBH1



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