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Descriptor English: Mechanistic Target of Rapamycin Complex 2
Descriptor Spanish: Diana Mecanicista del Complejo 2 de la Rapamicina
Descriptor diana mecanicista del complejo 2 de la rapamicina
Entry term(s) MTORC-2
TORC2
complejo TOR 2
diana del complejo 2 de la rapamicina
mTORC2
Scope note: Complejo multiproteínico constituido por la CINASA mTOR, la PROTEÍNA MLST8, la proteína insensible a la rapamicina asociada a mTOR (PROTEÍNA RICTOR) y la PRR5 (proteína 5 rica en prolina). Al igual que mTORC1, también regula el crecimiento y la proliferación celulares en respuesta a los factores de crecimiento, pero puede no ser tan sensible a la disponibilidad de nutrientes y es insensible al SIRÓLIMUS. A diferencia del mTORC1, puede regular el CITOESQUELETO DE ACTINA a través de las GTPASAS RHO para promover la formación de FIBRAS DE ESTRÉS. El complejo MTORC2 también desempeña un papel esencial en la fosforilación y activación de la proteincinasa AKT1.
Descriptor Portuguese: Alvo Mecanístico do Complexo 2 de Rapamicina
Descriptor French: Complexe-2 cible mécanistique de la rapamycine
Entry term(s): Complex 2, TOR
MTORC-2
TOR Complex 2
TORC2
Target of Rapamycin Complex 2
mTORC2
Tree number(s): D05.500.356
D08.811.913.696.620.682.700.931.750
D12.776.476.563.931.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076225
Scope note: A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.11.1
Public MeSH Note: 2018; see TOR COMPLEX 2 2013-2017; MECHANISTIC TARGET OF RAPAMYCIN 2 COMPLEX was indexed under MULTIPROTEIN COMPLEXES and TOR SERINE-THREONINE KINASES 2013-2017
History Note: 2018 (2013)
DeCS ID: 56985
Unique ID: D000076225
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2018/10/10
Mechanistic Target of Rapamycin Complex 2 - Preferred
Concept UI M0579319
Scope note A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.
Preferred term Mechanistic Target of Rapamycin Complex 2
Entry term(s) Complex 2, TOR
MTORC-2
TOR Complex 2
TORC2
Target of Rapamycin Complex 2
mTORC2



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