CHEMICALS AND DRUGS Macromolecular Substances [D05] Macromolecular Substances Multiprotein Complexes [D05.500] Multiprotein Complexes Amyloid [D05.500.049] Amyloid Apoptosomes [D05.500.099] Apoptosomes Axin Signaling Complex [D05.500.117] Axin Signaling Complex Calcifying Nanoparticles [D05.500.135] Calcifying Nanoparticles COP9 Signalosome Complex [D05.500.139] COP9 Signalosome Complex Dynactin Complex [D05.500.142] Dynactin Complex Dystrophin-Associated Protein Complex [D05.500.149] Dystrophin-Associated Protein Complex Endosomal Sorting Complexes Required for Transport [D05.500.199] Endosomal Sorting Complexes Required for Transport Inflammasomes [D05.500.224] Inflammasomes Lactose Synthase [D05.500.299] Lactose Synthase Mechanistic Target of Rapamycin Complex 1 [D05.500.337] Mechanistic Target of Rapamycin Complex 1 mTOR Associated Protein, LST8 Homolog [D05.500.337.250] mTOR Associated Protein, LST8 Homolog Regulatory-Associated Protein of mTOR [D05.500.337.500] Regulatory-Associated Protein of mTOR Mechanistic Target of Rapamycin Complex 2 [D05.500.356] Mechanistic Target of Rapamycin Complex 2 Mediator Complex [D05.500.374] Mediator Complex Mitochondrial Permeability Transition Pore [D05.500.437] Mitochondrial Permeability Transition Pore Mitochondrial Precursor Protein Import Complex Proteins [D05.500.469] Mitochondrial Precursor Protein Import Complex Proteins Molecular Motor Proteins [D05.500.500] Molecular Motor Proteins Multienzyme Complexes [D05.500.562] Multienzyme Complexes NF-kappa B [D05.500.672] NF-kappa B Polycomb-Group Proteins [D05.500.781] Polycomb-Group Proteins Protein Translocation Systems [D05.500.890] Protein Translocation Systems Shelterin Complex [D05.500.918] Shelterin Complex Troponin [D05.500.945] Troponin CHEMICALS AND DRUGS Enzymes and Coenzymes [D08] Enzymes and Coenzymes Enzymes [D08.811] Enzymes Transferases [D08.811.913] Transferases Phosphotransferases [D08.811.913.696] Phosphotransferases Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620] Phosphotransferases (Alcohol Group Acceptor) Protein Kinases [D08.811.913.696.620.682] Protein Kinases Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700] Protein Serine-Threonine Kinases TOR Serine-Threonine Kinases [D08.811.913.696.620.682.700.931] TOR Serine-Threonine Kinases Mechanistic Target of Rapamycin Complex 1 [D08.811.913.696.620.682.700.931.500] Mechanistic Target of Rapamycin Complex 1 mTOR Associated Protein, LST8 Homolog [D08.811.913.696.620.682.700.931.500.250] mTOR Associated Protein, LST8 Homolog Regulatory-Associated Protein of mTOR [D08.811.913.696.620.682.700.931.500.500] Regulatory-Associated Protein of mTOR Mechanistic Target of Rapamycin Complex 2 [D08.811.913.696.620.682.700.931.750] Mechanistic Target of Rapamycin Complex 2 CHEMICALS AND DRUGS Amino Acids, Peptides, and Proteins [D12] Amino Acids, Peptides, and Proteins Proteins [D12.776] Proteins Intracellular Signaling Peptides and Proteins [D12.776.476] Intracellular Signaling Peptides and Proteins Protein Serine-Threonine Kinases [D12.776.476.563] Protein Serine-Threonine Kinases TOR Serine-Threonine Kinases [D12.776.476.563.931] TOR Serine-Threonine Kinases Mechanistic Target of Rapamycin Complex 1 [D12.776.476.563.931.500] Mechanistic Target of Rapamycin Complex 1 mTOR Associated Protein, LST8 Homolog [D12.776.476.563.931.500.250] mTOR Associated Protein, LST8 Homolog Regulatory-Associated Protein of mTOR [D12.776.476.563.931.500.500] Regulatory-Associated Protein of mTOR Mechanistic Target of Rapamycin Complex 2 [D12.776.476.563.931.750] Mechanistic Target of Rapamycin Complex 2

Mechanistic Target of Rapamycin Complex 1 - Preferred

Concept UI	M0579317
Scope note	An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.
Preferred term	Mechanistic Target of Rapamycin Complex 1
Entry term(s)	Complex, mTORC1 TOR Complex 1 TORC1 Target of Rapamycin Complex 1 mTORC1 mTORC1 Complex