| Descriptor English: | Positive Regulatory Domain I-Binding Factor 1 | ||||||
| Descriptor Spanish: |
Factor 1 de Unión al Dominio 1 de Regulación Positiva
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| Descriptor Portuguese: | Fator 1 de Ligação ao Domínio I Regulador Positivo | ||||||
| Descriptor French: | Facteur-1 liant le domaine de régulation positive I | ||||||
| Entry term(s): |
B Lymphocyte Induced Maturation Protein 1 B Lymphocyte-Induced Maturation Protein 1 BLIMP1 Protein PRDI BF1 Protein PRDI-BF1 Protein PRDM1 Protein Positive Regulatory Domain I Binding Factor 1 |
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| Tree number(s): |
D08.811.913.555.500.800.700 D12.776.260.703.650 D12.776.930.780.904 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000074462 | ||||||
| Scope note: | A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.1.1.- | ||||||
| Previous Indexing: |
Repressor Proteins (1994-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| Related: |
PR-SET Domains
MeSH | ||||||
| DeCS ID: | 57030 | ||||||
| Unique ID: | D000074462 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/02 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Positive Regulatory Domain I-Binding Factor 1
- Preferred
| Concept UI |
M000626717 |
| Scope note | A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs. |
| Preferred term | Positive Regulatory Domain I-Binding Factor 1 |
| Entry term(s) |
B Lymphocyte Induced Maturation Protein 1 B Lymphocyte-Induced Maturation Protein 1 BLIMP1 Protein PRDI BF1 Protein PRDI-BF1 Protein PRDM1 Protein Positive Regulatory Domain I Binding Factor 1 |
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