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Descriptor English: Zinc Finger E-box-Binding Homeobox 1
Descriptor Spanish: Homeobox 1 de Unión a la E-Box con Dedos de Zinc
Descriptor caja homeótica de unión a la caja E con dedos de zinc
Entry term(s) factor de transcripción 8
factor de transcripción Zeb1
proteína TCF8
proteína con dedos de zinc NIL-2-A
Scope note: Factor de transcripción caracterizado por DEDOS DE ZINC CYS2-HIS2 N-terminales y C-terminales separados por una caja homeótica. Reprime la expresión de la E-CADHERINA para inducir la TRANSICIÓN EPITELIAL-MESENQUIMAL. También reprime las PROTEÍNAS PROTOONCOGÉNICAS C-BCL-6, regula la expresión específica de tipo celular de la ATPASA INTERCAMBIADORA DE SODIO-POTASIO y promueve la diferenciación neuronal.
Descriptor Portuguese: Homeobox 1 de Ligação a E-box em Dedo de Zinco
Descriptor French: Facteur de transcription Zeb1
Entry term(s): NIL 2 A Zinc Finger Protein
NIL-2-A Zinc Finger Protein
TCF8 Protein
Transcription Factor 8
Transcription Factor, Zeb1
Zeb1 Transcription Factor
Zinc Finger E box Binding Homeobox 1
Tree number(s): D12.776.260.400.906
D12.776.260.703.800
D12.776.930.780.945
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071799
Scope note: A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Homeodomain Proteins (2004-2016)
Transcription Factors (2004-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56604
Unique ID: D000071799
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15
Zinc Finger E-box-Binding Homeobox 1 - Preferred
Concept UI M000615551
Scope note A transcription factor characterized by N-terminal and C-terminal CYS2-HIS2 ZINC FINGERS separated by a homeobox. It represses the expression of E-CADHERIN to induce the EPITHELIAL-MESENCHYMAL TRANSITION. It also represses PROTO-ONCOGENE PROTEINS C-BCL-6; regulates the cell type-specific expression of SODIUM-POTASSIUM-EXCHANGING ATPASE; and promotes neuronal differentiation.
Preferred term Zinc Finger E-box-Binding Homeobox 1
Entry term(s) NIL 2 A Zinc Finger Protein
NIL-2-A Zinc Finger Protein
TCF8 Protein
Transcription Factor 8
Transcription Factor, Zeb1
Zeb1 Transcription Factor
Zinc Finger E box Binding Homeobox 1



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