| Descriptor English: | CCCTC-Binding Factor | ||||||
| Descriptor Spanish: |
Factor de Unión a CCCTC
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| Descriptor Portuguese: | Fator de Ligação a CCCTC | ||||||
| Descriptor French: | Facteur de liaison à la séquence CCCTC | ||||||
| Entry term(s): |
CCCTC Binding Factor CTCF Protein CTCF, DNA-Binding Protein DNA Binding Protein CTCF DNA-Binding Protein CTCF |
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| Tree number(s): |
D12.776.157.687.157 D12.776.260.120 D12.776.660.235.050 D12.776.660.720.157 D12.776.664.235.050 D12.776.930.780.563 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000076246 | ||||||
| Scope note: | A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Public MeSH Note: | 2018; CCCTC-BINDING FACTOR was indexed under REPRESSOR PROTEINS 2010-2017, under DNA-BINDING PROTEINS 1998-2009; and under TRANSCRIPTION FACTORS 1998-2004 |
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| History Note: | 2018 (1998) |
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| DeCS ID: | 57095 | ||||||
| Unique ID: | D000076246 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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CCCTC-Binding Factor
- Preferred
| Concept UI |
M0284805 |
| Scope note | A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING. |
| Preferred term | CCCTC-Binding Factor |
| Entry term(s) |
CCCTC Binding Factor CTCF Protein CTCF, DNA-Binding Protein DNA Binding Protein CTCF DNA-Binding Protein CTCF |
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