| Descriptor English: | Cytochrome P-450 CYP2B1 | ||||||
| Descriptor Spanish: |
Citocromo P-450 CYP2B1
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| Descriptor Portuguese: | Citocromo P-450 CYP2B1 | ||||||
| Descriptor French: | Cytochrome P-450 CYP2B1 | ||||||
| Entry term(s): |
7 Benzyloxyresorufin O Dealkylase 7 Pentylresorufin O Depentylase 7-Benzyloxyresorufin O-Dealkylase 7-Pentylresorufin O-Depentylase BROD Benzyloxyresorufin O Dealkylase Benzyloxyresorufin O-Dealkylase CYP 2B1 CYP2B1 Cytochrome P 450 CYP2B1 Cytochrome P450 2B1 O-Dealkylase, Pentoxyresorufin PROD Pentoxyresorufin O Dealkylase Pentoxyresorufin O-Dealkylase |
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| Tree number(s): |
D08.244.453.005.550 D08.244.453.491.313 D08.811.682.690.708.170.010.550 D08.811.682.690.708.170.450.313 D12.776.422.220.453.010.550 D12.776.422.220.453.491.313 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019362 | ||||||
| Scope note: | A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS. |
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| Annotation: | do not confuse with other cytochrome P-450 CYP's |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 1.14.14.1 | ||||||
| Previous Indexing: |
Cytochrome P-450 (1985-1996) Oxidoreductases (1985-1996) |
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| Public MeSH Note: | 97; PENTOXYRESORUFIN O-DEALKYLASE was indexed under CYTOCHROME P-450 & OXIDOREDUCTASES 1985-96 |
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| Online Note: | use CYTOCHROME P-450 CYP2B1 (NM) to search PENTOXYRESORUFIN O-DEALKYLASE 1985-96 |
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| History Note: | 97; was PENTOXYRESORUFIN O-DEALKYLASE (NM) 1985-96 |
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| DeCS ID: | 33010 | ||||||
| Unique ID: | D019362 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1997/01/01 | ||||||
| Date of Entry: | 1996/06/13 | ||||||
| Revision Date: | 2016/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Cytochrome P-450 CYP2B1
- Preferred
| Concept UI |
M0028816 |
| Scope note | A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS. |
| Preferred term | Cytochrome P-450 CYP2B1 |
| Entry term(s) |
7 Benzyloxyresorufin O Dealkylase 7 Pentylresorufin O Depentylase 7-Benzyloxyresorufin O-Dealkylase 7-Pentylresorufin O-Depentylase BROD Benzyloxyresorufin O Dealkylase Benzyloxyresorufin O-Dealkylase CYP 2B1 CYP2B1 Cytochrome P 450 CYP2B1 Cytochrome P450 2B1 O-Dealkylase, Pentoxyresorufin PROD Pentoxyresorufin O Dealkylase Pentoxyresorufin O-Dealkylase |
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