| Descriptor English: | Cytochrome P-450 CYP2D6 | ||||||
| Descriptor Spanish: |
Citocromo P-450 CYP2D6
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| Descriptor Portuguese: | Citocromo P-450 CYP2D6 | ||||||
| Descriptor French: | Cytochrome P-450 CYP2D6 | ||||||
| Entry term(s): |
2-Hydroxylase, Imipramine 4-Hydroxylase, Debrisoquine 4-Monooxygenase, Debrisoquine CYP 2D6 CYP2D6 CYP2D6, Cytochrome P-450 Cytochrome P 450 CYP2D6 Cytochrome P450 2D6 Debrisoquine 4 Hydroxylase Debrisoquine 4 Monooxygenase Debrisoquine 4-Hydroxylase Debrisoquine 4-Monooxygenase Debrisoquine Hydroxylase Hydroxylase, Debrisoquine Imipramine 2 Hydroxylase Imipramine 2-Hydroxylase Monooxygenase, Sparteine P-450 CYP2D6, Cytochrome P450 2D6, Cytochrome Sparteine Monooxygenase |
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| Tree number(s): |
D08.244.453.005.600 D08.244.453.491.372 D08.811.682.690.708.170.010.600 D08.811.682.690.708.170.450.368 D12.776.422.220.453.010.600 D12.776.422.220.453.491.368 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019389 | ||||||
| Scope note: | A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
antagonists & inhibitors:Cytochrome P-450 CYP2D6 Inhibitors
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| Registry Number: | EC 1.14.14.1 | ||||||
| Previous Indexing: |
Cytochrome P-450 (1975-1996) Hydroxylases (1979-1996) |
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| Public MeSH Note: | 97; DEBRISOQUINE 4-HYDROXYLASE was indexed under CYTOCHROME P-450 & HYDROXYLASES 1982-96 |
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| Online Note: | use CYTOCHROME P-450 CYP2D6 (NM) to search DEBRISOQUINE 4-HYDROXYLASE 1982-96 |
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| History Note: | 97; was DEBRISOQUINE 4-HYDROXYLASE (NM) 1982-96 |
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| DeCS ID: | 33011 | ||||||
| Unique ID: | D019389 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1997/01/01 | ||||||
| Date of Entry: | 1996/06/13 | ||||||
| Revision Date: | 2016/05/27 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Cytochrome P-450 CYP2D6
- Preferred
| Concept UI |
M0028855 |
| Scope note | A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population. |
| Preferred term | Cytochrome P-450 CYP2D6 |
| Entry term(s) |
2-Hydroxylase, Imipramine 4-Hydroxylase, Debrisoquine 4-Monooxygenase, Debrisoquine CYP 2D6 CYP2D6 CYP2D6, Cytochrome P-450 Cytochrome P 450 CYP2D6 Cytochrome P450 2D6 Debrisoquine 4 Hydroxylase Debrisoquine 4 Monooxygenase Debrisoquine 4-Hydroxylase Debrisoquine 4-Monooxygenase Debrisoquine Hydroxylase Hydroxylase, Debrisoquine Imipramine 2 Hydroxylase Imipramine 2-Hydroxylase Monooxygenase, Sparteine P-450 CYP2D6, Cytochrome P450 2D6, Cytochrome Sparteine Monooxygenase |
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