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Descriptor English: Complement C1
Descriptor Spanish: Complemento C1
Descriptor complemento C1
Entry term(s) C1 del complemento
complemento 1
componente 1 del complemento
Scope note: El primer componente del complemento que actúa en la activación de la VÍA CLÁSICA DEL COMPLEMENTO. Es un complejo trimolecular dependiente del calcio compuesto de tres subcomponentes: COMPLEMENTO C1Q, COMPLEMENTO C1R Y COMPLEMENTO C1S en proporciones de 1:2:2. Cuando el C1 intacto se une al menos a dos anticuerpos (que implican C1q), C1r y C1s son activados secuencialmente, lo que lleva a etapas posteriores en la cascada de la ACTIVACIÓN DEL COMPLEMENTO.
Descriptor Portuguese: Complemento C1
Descriptor French: Complément C1
Entry term(s): Composant C1 du complément
Facteur C1 du complément
Fraction C1 du complément
Tree number(s): D12.776.124.486.274.050
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003172
Scope note: The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
Annotation: /antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
DeCS ID: 22133
Unique ID: D003172
NLM Classification: QW 680
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2013/07/09
Complément C1 - Preferred
Concept UI M0004924
Preferred term Complément C1
Entry term(s) Composant C1 du complément
Facteur C1 du complément
Fraction C1 du complément



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