DeCS

Descriptor English:

Neprilysin

Descriptor Spanish:

Neprilisina

Spanish from Spain

Descriptor	neprilisina
Entry term(s)	antígeno CALLA antígenos CD10 antígenos comunes de la leucemia linfoblástica aguda encefalina dipeptidil carboxipeptidasa encefalinasa endopeptidasa 24.11 endopeptidasa neutra metaloendopeptidasa de membrana proteinasa neutra de célula renal con borde en cepillo
Scope note:	Enzima que es el constituyente principal de las membranas de las células renales con borde en cepillo y también está presente, en menor grado, en el encéfalo y otros tejidos. Cataliza preferentemente la escisión del grupo amino de los residuos hidrófobos de la cadena B de la insulina, así como de péptidos opioides y de otros péptidos biológicamente activos. La enzima es inhibida principalmente por el EDTA, el fosforamidón y el tiorfano, y es reactivada por el zinc. La neprilisina es idéntica al antígeno común de la leucemia linfoblástica aguda (antígeno CALLA), un marcador importante en el diagnóstico de la leucemia linfocítica aguda humana. No existe relación con la PLANTA CALLA.

Descriptor Portuguese:

Neprilisina

Descriptor French:

Néprilysine

Entry term(s):

Antigen, CD10
Antigens, CD10
Antigens, Leukemia, Common Acute Lymphoblastic
Atriopeptidase
CALLA Antigen
CD10 Antigen
CD10 Antigens
Carboxypeptidase, Enkephalin Dipeptidyl
Common Acute Lymphoblastic Leukemia Antigens
Dipeptidyl Carboxypeptidase, Enkephalin
Endopeptidase 24.11
Endopeptidase 24.11, Neutral
Endopeptidase, Neutral
Endopeptidase-24.11
Enkephalin Dipeptidyl Carboxypeptidase
Enkephalinase
Enkephalinase 24.11
Enkephalinase-24.11
Enzyme, YGG-Forming
Kidney Brush Border Neutral Proteinase
Kidney-Brush-Border Neutral Proteinase
Membrane Metallo Endopeptidase
Membrane Metallo-Endopeptidase
Metallo-Endopeptidase, Membrane
Metalloendopeptidase, Thermolysin-Like
Neutral Endopeptidase
Neutral Endopeptidase 24.11
Neutral Proteinase, Kidney-Brush-Border
Thermolysin Like Metalloendopeptidase
Thermolysin-Like Metalloendopeptidase
YGG Forming Enzyme
YGG-Forming Enzyme

Tree number(s):

D08.811.277.656.300.480.600
D08.811.277.656.675.374.600
D23.050.285.550
D23.101.140.500

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D015260

Scope note:

Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Registry Number:

EC 3.4.24.11

Previous Indexing:

Metalloproteinases (1987-1988)
Peptide Peptidohydrolases (1966-1987)

Public MeSH Note:

1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was indexed under ANTIGENS, NEOPLASM & ANTIGENS, DIFFERENTIATION 1983-92; for CALLA ANTIGEN see CALLA 1993-2002

Online Note:

use NEPRILYSIN (NM) to search COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS 1983-92

History Note:

1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92

Concept UI	M0023500
Scope note	Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.
Preferred term	Neprilysin
Entry term(s)	Antigen, CD10 Antigens, CD10 Antigens, Leukemia, Common Acute Lymphoblastic Atriopeptidase CALLA Antigen CD10 Antigen CD10 Antigens Carboxypeptidase, Enkephalin Dipeptidyl Common Acute Lymphoblastic Leukemia Antigens Dipeptidyl Carboxypeptidase, Enkephalin Endopeptidase 24.11 Endopeptidase 24.11, Neutral Endopeptidase, Neutral Endopeptidase-24.11 Enkephalin Dipeptidyl Carboxypeptidase Enkephalinase Enkephalinase 24.11 Enkephalinase-24.11 Enzyme, YGG-Forming Kidney Brush Border Neutral Proteinase Kidney-Brush-Border Neutral Proteinase Membrane Metallo Endopeptidase Membrane Metallo-Endopeptidase Metallo-Endopeptidase, Membrane Metalloendopeptidase, Thermolysin-Like Neutral Endopeptidase Neutral Endopeptidase 24.11 Neutral Proteinase, Kidney-Brush-Border Thermolysin Like Metalloendopeptidase Thermolysin-Like Metalloendopeptidase YGG Forming Enzyme YGG-Forming Enzyme

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