| Descriptor English: | Proprotein Convertase 9 | ||||||
| Descriptor Spanish: |
Proproteína Convertasa 9
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| Descriptor Portuguese: | Pró-Proteína Convertase 9 | ||||||
| Descriptor French: | Proprotéine convertase 9 | ||||||
| Entry term(s): |
Convertase 9, Proprotein NARC 1 Protein NARC-1 Protein Neural Apoptosis Regulated Convertase 1 Neural Apoptosis-Regulated Convertase 1 Proprotein Convertase, Subtilisin Kexin Type 9 Proprotein Convertase, Subtilisin-Kexin Type 9 |
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| Tree number(s): |
D08.811.277.656.300.760.718 D08.811.277.656.837.688 D08.811.277.656.959.350.718 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000071449 | ||||||
| Scope note: | A proprotein convertase that is essential for CHOLESTEROL homeostasis. It binds to and is required for the lysosomal degradation of the LDL RECEPTOR (LDLR); the VLDL receptor, and the APOLIPOPROTEIN E RECEPTOR. It also regulates neuronal APOPTOSIS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
antagonists & inhibitors:PCSK9 Inhibitors
antagonistas & inhibidores:Inhibidores de PCSK9 antagonistas & inibidores:Inibidores de PCSK9 |
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| Registry Number: | EC 3.4.21.- | ||||||
| Previous Indexing: |
Proprotein Convertases (2003-2016) Serine Endopeptidases (2003-2016) |
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| Public MeSH Note: | 2017 |
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| History Note: | 2017 |
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| DeCS ID: | 56481 | ||||||
| Unique ID: | D000071449 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2017/01/01 | ||||||
| Date of Entry: | 2016/07/08 | ||||||
| Revision Date: | 2016/07/05 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Proprotein Convertase 9
- Preferred
| Concept UI |
M000614708 |
| Scope note | A proprotein convertase that is essential for CHOLESTEROL homeostasis. It binds to and is required for the lysosomal degradation of the LDL RECEPTOR (LDLR); the VLDL receptor, and the APOLIPOPROTEIN E RECEPTOR. It also regulates neuronal APOPTOSIS. |
| Preferred term | Proprotein Convertase 9 |
| Entry term(s) |
Convertase 9, Proprotein NARC 1 Protein NARC-1 Protein Neural Apoptosis Regulated Convertase 1 Neural Apoptosis-Regulated Convertase 1 Proprotein Convertase, Subtilisin Kexin Type 9 Proprotein Convertase, Subtilisin-Kexin Type 9 |
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