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Descriptor English: Proprotein Convertase 9
Descriptor Spanish: Proproteína Convertasa 9
Descriptor Portuguese: Pró-Proteína Convertase 9
Descriptor French: Proprotéine convertase 9
Entry term(s): Convertase 9, Proprotein
NARC 1 Protein
NARC-1 Protein
Neural Apoptosis Regulated Convertase 1
Neural Apoptosis-Regulated Convertase 1
Proprotein Convertase, Subtilisin Kexin Type 9
Proprotein Convertase, Subtilisin-Kexin Type 9
Tree number(s): D08.811.277.656.300.760.718
D08.811.277.656.837.688
D08.811.277.656.959.350.718
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000071449
Scope note: A proprotein convertase that is essential for CHOLESTEROL homeostasis. It binds to and is required for the lysosomal degradation of the LDL RECEPTOR (LDLR); the VLDL receptor, and the APOLIPOPROTEIN E RECEPTOR. It also regulates neuronal APOPTOSIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.-
Previous Indexing: Proprotein Convertases (2003-2016)
Serine Endopeptidases (2003-2016)
Public MeSH Note: 2017
History Note: 2017
DeCS ID: 56481
Unique ID: D000071449
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/05
Proprotein Convertase 9 - Preferred
Concept UI M000614708
Scope note A proprotein convertase that is essential for CHOLESTEROL homeostasis. It binds to and is required for the lysosomal degradation of the LDL RECEPTOR (LDLR); the VLDL receptor, and the APOLIPOPROTEIN E RECEPTOR. It also regulates neuronal APOPTOSIS.
Preferred term Proprotein Convertase 9
Entry term(s) Convertase 9, Proprotein
NARC 1 Protein
NARC-1 Protein
Neural Apoptosis Regulated Convertase 1
Neural Apoptosis-Regulated Convertase 1
Proprotein Convertase, Subtilisin Kexin Type 9
Proprotein Convertase, Subtilisin-Kexin Type 9



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