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Descriptor English: Furin
Descriptor Spanish: Furina
Descriptor Portuguese: Furina
Descriptor French: Furine
Entry term(s): Dibasic Processing Enzyme
Furin Protein
Paired Basic Amino Acid Cleaving Enzyme
Processing Enzyme, Dibasic
SPC1 Proteinase
Tree number(s): D08.811.277.656.300.760.353
D08.811.277.656.837.249
D08.811.277.656.959.350.353
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D045683
Scope note: A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.75
Previous Indexing: Serine Endopeptidases (1989-1992)
Subtilisins (1993-2003)
Public MeSH Note: 2004; FURIN was indexed under SUBTILISINS 1993-2003
History Note: 2004; use FURIN (NM) 1993-2003
DeCS ID: 38168
Unique ID: D045683
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2009/07/06
Furin - Preferred
Concept UI M0212390
Scope note A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
Preferred term Furin
Entry term(s) Dibasic Processing Enzyme
Furin Protein
Paired Basic Amino Acid Cleaving Enzyme
Processing Enzyme, Dibasic
SPC1 Proteinase



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