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Descriptor English: Proprotein Convertase 1
Descriptor Spanish: Proproteína Convertasa 1
Descriptor proproteína convertasa 1
Entry term(s) prohormona convertasa PC1
Scope note: Endopeptidasa dependiente del CALCIO con especificidad para la escisión en la ARGININA que está junto a residuos básicos pareados. Escinde diversas prohormonas, como la PROOPIOMELANOCORTINA, la PRORRENINA, las proencefalinas, la prodinorfina, la prosomatostatina y la PROINSULINA.
Descriptor Portuguese: Pró-Proteína Convertase 1
Descriptor French: Proprotein convertase 1
Entry term(s): Convertase 1, Proprotein
Convertase PC1, Neuroendocrine
Convertase SPC3, Proprotein
Convertase, PC1 Prohormone
Convertase, PC3 Prohormone
Endoprotease, PC1
Endoprotease, PC3
Neuroendocrine Convertase PC1
PC1 Endoprotease
PC1 Prohormone Convertase
PC3 Endoprotease
PC3 Prohormone Convertase
Prohormone Convertase 1
Prohormone Convertase 3
Prohormone Convertase, PC1
Prohormone Convertase, PC3
Proinsulin Convertase 1
Proprotein Convertase SPC3
Tree number(s): D08.811.277.656.300.760.640
D08.811.277.656.837.500
D08.811.277.656.959.350.640
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D045664
Scope note: A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.21.93
Previous Indexing: Aspartic Endopeptidases (1991-2003)
Public MeSH Note: 2004; PC1 PROHORMONE CONVERTASE, NEUROENDOCRINE CONVERTASE PC1, PC3 ENDOPROTEASE & PROHORMONE CONVERTASE 1 were indexed under ASPARTIC ENDOPEPTIDASES 1991-2003; PC1 ENDOPROTEASE & PC3 PROHORMONE CONVERTASE were indexed under ASPARTIC ENDOPEPTIDASES 1993-2003; PROPROTEIN CONVERTASE SPC3 was indexed under ASPARTIC ENDOPEPTIDASES 2001-2003; PROINSULIN CONVERTASE 1 was indexed under ASPARTIC ENDOPEPTIDASES 2002-2003;
History Note: 2004; for PC1 PROHORMONE CONVERTASE, NEUROENDOCRINE CONVERTASE PC1, PC3 ENDOPROTEASE, PROHORMONE CONVERTASE 1 use PROPROTEIN CONVERTASE (NM) 1991-2003; for PC1 ENDOPROTEASE & PC3 PROHORMONE CONVERTASE use PROPROTEIN CONVERTASE (NM) 1993-2003; for PROPROTEIN CONVERTASE SPC3 use PROPROTEIN CONVERTASE (NM) 2001-2003; for PROINSULIN CONVERTASE 1 use PROPROTEIN CONVERTASE (NM) 2002-2003
DeCS ID: 38169
Unique ID: D045664
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2009/07/06
Proprotein Convertase 1 - Preferred
Concept UI M0103931
Scope note A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
Preferred term Proprotein Convertase 1
Entry term(s) Convertase 1, Proprotein
Convertase PC1, Neuroendocrine
Convertase SPC3, Proprotein
Convertase, PC1 Prohormone
Convertase, PC3 Prohormone
Endoprotease, PC1
Endoprotease, PC3
Neuroendocrine Convertase PC1
PC1 Endoprotease
PC1 Prohormone Convertase
PC3 Endoprotease
PC3 Prohormone Convertase
Prohormone Convertase 1
Prohormone Convertase 3
Prohormone Convertase, PC1
Prohormone Convertase, PC3
Proinsulin Convertase 1
Proprotein Convertase SPC3



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