| Descriptor English: | Neurofilament Proteins | ||||||
| Descriptor Spanish: |
Proteínas de Neurofilamentos
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| Descriptor Portuguese: | Proteínas de Neurofilamentos | ||||||
| Descriptor French: | Protéines neurofilamenteuses | ||||||
| Entry term(s): |
Heavy Neurofilament Protein Neurofilament Protein Neurofilament Protein, Heavy Neurofilament Triplet Proteins Protein, Heavy Neurofilament Protein, Neurofilament Proteins, Neurofilament Proteins, Neurofilament Triplet Triplet Proteins, Neurofilament |
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| Tree number(s): |
D05.750.078.593.630 D12.776.220.475.630 D12.776.631.630 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D016900 | ||||||
| Scope note: | Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302) |
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| Annotation: | /biosyn /physiol permitted |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Intermediate Filament Proteins (1982-1991) Nerve Tissue Proteins (1970-1982) |
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| Public MeSH Note: | 92; NEUROFILAMENT PROTEINS was indexed under INTERMEDIATE FILAMENT PROTEINS 1982-91 & NERVE TISSUE PROTEINS 1977-82 |
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| Online Note: | use NEUROFILAMENT PROTEINS (NM) to search NEUROFILAMENT PROTEINS 1977-91 |
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| History Note: | 92; was NEUROFILAMENT PROTEINS (NM) 1977-91 |
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| DeCS ID: | 29931 | ||||||
| Unique ID: | D016900 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1992/01/01 | ||||||
| Date of Entry: | 1991/05/30 | ||||||
| Revision Date: | 2020/06/17 |
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CHEMICALS AND DRUGS
Macromolecular Substances [D05]Macromolecular Substances -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Neurofilament Proteins
- Preferred
Neurofilament Triplet Proteins
- Narrower
Heavy Neurofilament Protein
- Narrower
| Concept UI |
M0025716 |
| Scope note | Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302) |
| Preferred term | Neurofilament Proteins |
| Entry term(s) |
Neurofilament Protein Protein, Neurofilament Proteins, Neurofilament |
| Concept UI |
M0025718 |
| Preferred term | Neurofilament Triplet Proteins |
| Entry term(s) |
Proteins, Neurofilament Triplet Triplet Proteins, Neurofilament |
| Concept UI |
M0025717 |
| Preferred term | Heavy Neurofilament Protein |
| Entry term(s) |
Neurofilament Protein, Heavy Protein, Heavy Neurofilament |
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