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Descriptor English: Neurexins
Descriptor Spanish: Neurexinas
Descriptor neurexinas
Scope note: Moléculas de adhesión celular presinápticas que se unen a NEUROLIGINAS postsinápticas para formar adhesiones transinápticas dependientes de calcio. Las neurexinas reclutan proteínas de andamiaje sináptico a través de sus DOMINIOS PDZ. La distribución y la interacción con las neuroliginas están reguladas por EMPALME ALTERNATIVO. Las alteraciones en los genes que codifican las neurexinas se asocian a enfermedades cognitivas como el TRASTORNO DEL ESPECTRO DEL AUTISMO, la ESQUIZOFRENIA y el síndrome similar al síndrome Pitt-Hopkins de tipo 2.
Descriptor Portuguese: Neurexinas
Descriptor French: Without translation
Tree number(s): D09.400.430.890.200.250.640
D12.776.395.550.200.250.640
D12.776.543.550.200.250.760
D12.776.631.609
D23.050.301.350.250.760
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000096784
Scope note: Presynaptic cell-adhesion molecules that bind postsynaptic NEUROLIGINS to form calcium-dependent trans-synaptic adhesions. Neurexins recruit synaptic scaffolding proteins via their PDZ DOMAINS. Distribution and interaction with neuroligins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neurexins are associated with cognitive diseases such AUTISM SPECTRUM DISORDER; SCHIZOPHRENIA and Pitt-Hopkins-like syndrome 2.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nerve Tissue Proteins (1992-2023)
Public MeSH Note: 2024
History Note: 2024
DeCS ID: 60518
Unique ID: D000096784
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/04/05
Neurexins - Preferred
Concept UI M000762630
Scope note Presynaptic cell-adhesion molecules that bind postsynaptic NEUROLIGINS to form calcium-dependent trans-synaptic adhesions. Neurexins recruit synaptic scaffolding proteins via their PDZ DOMAINS. Distribution and interaction with neuroligins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neurexins are associated with cognitive diseases such AUTISM SPECTRUM DISORDER; SCHIZOPHRENIA and Pitt-Hopkins-like syndrome 2.
Preferred term Neurexins



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