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Descriptor English: Synapsins
Descriptor Spanish: Sinapsinas
Descriptor sinapsinas
Entry term(s) sinapsina
sinapsina I
sinapsina II
sinapsina III
Scope note: Familia de proteínas asociadas a las vesículas sinápticas, que participan en la regulación a corto plazo de la liberación de NEUROTRANSMISORES. La sinapsina I, miembro predominante de esta familia, une las VESICULAS SINÁPTICAS a los FILAMENTOS DE ACTINA en la terminal nerviosa presináptica. Estas interacciones son moduladas por la FOSFORILACIÓN reversible de la sinapsina I por medio de varias vías de señales de transducción. La proteína también es un sustrato para cAMP y las PROTEINA QUINASA DEPENDIENTE DE CA(2+)-CALMODULINA. Se cree que estas propiedades funcionales son compartidas también por la sinapsina II.
Descriptor Portuguese: Sinapsinas
Descriptor French: Synapsine
Entry term(s): Synapsin
Synapsin I
Synapsin II
Synapsin III
Tree number(s): D12.776.631.750
D12.776.744.840
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016704
Scope note: A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Nerve Tissue Proteins (1966-1991)
Neuropeptides (1987-1991)
Phosphoproteins (1970-1991)
Public MeSH Note: 1992
History Note: 1992; use SYNAPSINS (NM) 1981-1991
DeCS ID: 29796
Unique ID: D016704
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/07/12
Revision Date: 2020/05/27
Synapsins - Preferred
Concept UI M0025442
Scope note A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
Preferred term Synapsins
Entry term(s) Synapsin
Synapsin II - Narrower
Concept UI M0025445
Preferred term Synapsin II
Synapsin III - Narrower
Concept UI M0025443
Preferred term Synapsin III
Synapsin I - Narrower
Concept UI M0025444
Preferred term Synapsin I



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