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Descriptor English: Disks Large Homolog 4 Protein
Descriptor Spanish: Homólogo 4 de la Proteína Discs Large
Descriptor homólogo 4 de la proteína discs large
Entry term(s) proteína 90 asociada a la sinapsis
proteína 95 de la densidad post-sináptica
proteína PSD-95
proteína PSD95
proteína SAP-90
proteína SAP90
Scope note: Proteína neuronal que contiene tres DOMINIOS PDZ, un DOMINIO SH3 y una región C-terminal tipo guanilato cinasa (ver PROTEÍNAS MAGUK). Se localiza en la DENSIDAD POST-SINÁPTICA y se asocia a la cola citoplasmática de los RECEPTORES NMDA y los CANALES DE POTASIO SHAKER; juega un papel crítico en la PLASTICIDAD SINÁPTICA mediada por el receptor NMDA.
Descriptor Portuguese: Proteína 4 Homóloga a Disks-Large
Descriptor French: Homologue-4 de la protéine Disks Large
Entry term(s): Discs Large Homolog 4 Protein
PSD 95 Protein
PSD-95 Protein
PSD95 Protein
Postsynaptic Density Protein 95
SAP 90 Protein
SAP-90 Protein
SAP90 Protein
Synapse Associated Protein 90
Synapse-Associated Protein 90
Tree number(s): D08.811.913.696.650.450.750
D12.644.360.265
D12.776.476.265
D12.776.543.219
D12.776.631.224
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000076122
Scope note: A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Intracellular Signaling Peptides and Proteins (2005-2017)
Membrane Proteins (2005-2017)
Public MeSH Note: 2018
History Note: 2018
Related: SAP90-PSD95 Associated Proteins MeSH
DeCS ID: 57036
Unique ID: D000076122
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
Disks Large Homolog 4 Protein - Preferred
Concept UI M000632224
Scope note A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.
Preferred term Disks Large Homolog 4 Protein
Entry term(s) Discs Large Homolog 4 Protein
PSD 95 Protein
PSD-95 Protein
PSD95 Protein
Postsynaptic Density Protein 95
SAP 90 Protein
SAP-90 Protein
SAP90 Protein
Synapse Associated Protein 90
Synapse-Associated Protein 90



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