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Descriptor English: Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
Descriptor Spanish: Subunidad Apc2 del Ciclosoma-Complejo Promotor de la Anafase
Descriptor subunidad Apc2 del complejo promotor de la anafase-ciclosoma
Entry term(s) Anapc2
subunidad Apc2 del ciclosoma
subunidad Apc2 del ciclosoma o complejo promotor de la anafase
subunidad Apc2 del complejo promotor de la anafase
subunidad Apc2 del complejo promotor de la anafase o ciclosoma
Scope note: Junto a la subunidad Apc11, forma el núcleo catalítico de la ubicuitina ligasa E3- complejo promotor de la anafase-ciclosoma (APC-C). Su N-terminal contiene dominios culina que se asocian a los DOMINIOS RING FINGERS de Apc11. Apc2 también interactúa con las ubiquitina ligasas E2 implicadas con las reacciones de ubiquitinación APC-C.
Descriptor Portuguese: Subunidade Apc2 do Ciclossomo-Complexo Promotor de Anáfase
Descriptor French: Sous-unité APC2 du complexe promoteur de l'anaphase
Entry term(s): Anapc2
Apc2 Subunit, Anaphase Promoting Complex
Apc2 Subunit, Anaphase Promoting Complex Cyclosome
Apc2 Subunit, Anaphase-Promoting Complex
Tree number(s): D08.811.464.938.750.092.750
D12.776.167.024.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064190
Scope note: Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.3.2.27
Previous Indexing: Cell Cycle Proteins (1996-2003)
Ligases (1996-2003)
Ubiquitin-Protein Ligase Complexes (2003-2013)
Public MeSH Note: 2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013
History Note: 2014
DeCS ID: 55276
Unique ID: D064190
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2016/06/02
Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome - Preferred
Concept UI M0580157
Scope note Together with the Apc11 subunit, forms the catalytic core of the E3 ubiquitin ligase anaphase-promoting complex (APC-C). Its N-terminus has cullin domains which associate with the RING FINGER DOMAINS of Apc11. Apc2 also interacts with the E2 ubiquitin ligases involved in APC-C ubiquitination reactions.
Preferred term Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome
Entry term(s) Anapc2
Apc2 Subunit, Anaphase Promoting Complex
Apc2 Subunit, Anaphase Promoting Complex Cyclosome
Apc2 Subunit, Anaphase-Promoting Complex



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