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Descriptor English: Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
Descriptor Spanish: Subunidad Apc8 del Ciclosoma-Complejo Promotor de la Anafase
Descriptor subunidad Apc8 del complejo promotor de la anafase-ciclosoma
Entry term(s) Anapc8
subunidad Apc8 del ciclosoma
subunidad Apc8 del ciclosoma o complejo promotor de la anafase
subunidad Apc8 del complejo promotor de la anafase
subunidad Apc8 del complejo promotor de la anafase o ciclosoma
Scope note: Subunidad del complejo promotor de la anafase altamente conservada del complejo promotor de la anafase (APC-C) que contiene múltiples repeticiones de tetratricopéptido de 34 aminoácidos. Estos dominios, que también se encuentran en Apc3, Apc6 y Apc7 median interacciones proteína-proteína lo que sugiere que la Apc8 interviene en la coordinación de la yuxtaposición de las subunidades de reconocimiento del sustrato y catalítica relacionadas con coactivadores e inhibidores de APC-C.
Descriptor Portuguese: Subunidade Apc8 do Ciclossomo-Complexo Promotor de Anáfase
Descriptor French: Sous-unité APC8 du complexe promoteur de l'anaphase
Entry term(s): Anapc8
Apc8 Subunit, Anaphase Promoting Complex
Apc8 Subunit, Anaphase Promoting Complex Cyclosome
Apc8 Subunit, Anaphase-Promoting Complex
Tree number(s): D08.811.464.938.750.092.996
D12.776.167.024.996
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D064196
Scope note: A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc7, have been shown to mediate protein-protein interactions, suggesting that Apc8 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Cell Cycle Proteins (1996-2013)
Ligases (1996-2003)
Ubiquitin-Protein Ligase Complexes (2004-2013)
Public MeSH Note: 2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013
History Note: 2014
DeCS ID: 55282
Unique ID: D064196
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome - Preferred
Concept UI M0580183
Scope note A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc7, have been shown to mediate protein-protein interactions, suggesting that Apc8 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
Preferred term Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
Entry term(s) Anapc8
Apc8 Subunit, Anaphase Promoting Complex
Apc8 Subunit, Anaphase Promoting Complex Cyclosome
Apc8 Subunit, Anaphase-Promoting Complex



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