| Descriptor English: | Anaphase-Promoting Complex-Cyclosome | ||||||
| Descriptor Spanish: |
Ciclosoma-Complejo Promotor de la Anafase
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| Descriptor Portuguese: | Ciclossomo-Complexo Promotor de Anáfase | ||||||
| Descriptor French: | Complexe promoteur de l'anaphase | ||||||
| Entry term(s): |
Anaphase Promoting Complex |
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| Tree number(s): |
D08.811.464.938.750.092 D12.776.167.024 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D064173 | ||||||
| Scope note: | An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.3.2.27 | ||||||
| Previous Indexing: |
Ligases (1992-2003) Ubiquitin-Protein Ligase Complexes (2004-2013) |
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| Public MeSH Note: | 2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013 |
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| History Note: | 2014 |
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| DeCS ID: | 55272 | ||||||
| Unique ID: | D064173 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2014/01/01 | ||||||
| Date of Entry: | 2013/07/08 | ||||||
| Revision Date: | 2016/06/02 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Anaphase-Promoting Complex-Cyclosome
- Preferred
| Concept UI |
M0580077 |
| Scope note | An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the PLACENTA, CRYSTALLINE LENS, and SKELETAL MUSCLE, and in regulation of postmitotic NEURONAL PLASTICITY and excitability. |
| Preferred term | Anaphase-Promoting Complex-Cyclosome |
| Entry term(s) |
Anaphase Promoting Complex |
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