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Descriptor English: Donepezil
Descriptor Spanish: Donepezilo
Descriptor donepezilo
Entry term(s) Aricept
E 2020
E-2020
E2020
Eranz
hidrocloruro de 1-bencil-4-((5,6-dimetoxi-1-indanon)-2-il)metilpiperidina
hidrocloruro de donepezil
oxalato de donepezilo trihidratado
Scope note: Derivado de indano y piperidina que actúa como inhibidor selectivo y reversible de la ACETILCOLINESTERASA. El donepezilo presenta una selectividad alta por el sistema nervioso central y se usa en el tratamiento de la DEMENCIA de leve a moderada en la ENFERMEDAD DE ALZHEIMER.
Descriptor Portuguese: Donepezila
Descriptor French: Donépézil
Entry term(s): 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride
Aricept
Donepezil Hydrochloride
Donepezilium Oxalate Trihydrate
E 2020
E-2020
E2020
Eranz
Tree number(s): D02.455.426.559.847.486.487.280
D03.383.621.238
D04.615.486.487.280
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077265
Scope note: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Cholinesterase Inhibitors
Nootropic Agents
Registry Number: 8SSC91326P
CAS Type 1 Name: 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)methyl)-
Public MeSH Note: 2019; DONEPEZIL was indexed under INDANS and PIPERIDINES 1992-2018
History Note: 2019 (1992)
DeCS ID: 57568
Unique ID: D000077265
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/07/03
Donepezil - Preferred
Concept UI M0206795
Scope note An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
Preferred term Donepezil
Eranz - Narrower
Concept UI M0477713
Preferred term Eranz
Donepezilium Oxalate Trihydrate - Narrower
Concept UI M0507746
Preferred term Donepezilium Oxalate Trihydrate
E 2020 - Narrower
Concept UI M0206796
Preferred term E 2020
Entry term(s) E-2020
E2020
Donepezil Hydrochloride - Narrower
Concept UI M0206791
Preferred term Donepezil Hydrochloride
Entry term(s) 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride
Aricept - Narrower
Concept UI M0206792
Preferred term Aricept



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