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Descriptor English: Crizotinib
Descriptor Spanish: Crizotinib
Descriptor Portuguese: Crizotinibe
Descriptor French: Crizotinib
Entry term(s): PF 02341066
PF 2341066
PF-02341066
PF-2341066
PF02341066
PF2341066
Xalkori
Tree number(s): D03.383.621.154
D03.383.725.050.263
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077547
Scope note: A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Protein Kinase Inhibitors
Registry Number: 53AH36668S
CAS Type 1 Name: 2-Pyridinamine, 3-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(4-piperidinyl)-1H-pyrazol-4-yl)-
Public MeSH Note: 2010; CRIZOTINIB was indexed under PYRAZOLES and PYRIDINES 2010-2018
History Note: 2019 (2010)
DeCS ID: 57672
Unique ID: D000077547
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Crizotinib - Preferred
Concept UI M0553416
Scope note A piperidine and aminopyridine derivative that acts as an inhibitor of RECEPTOR PROTEIN-TYROSINE KINASES, including ANAPLASTIC LYMPHOMA KINASE (ALK) and HEPATOCYTE GROWTH FACTOR RECEPTOR (HGFR; c-Met). It is used in the treatment of NON-SMALL CELL LUNG CANCER.
Preferred term Crizotinib
PF-02341066 - Narrower
Concept UI M0549737
Preferred term PF-02341066
Entry term(s) PF 02341066
PF 2341066
PF-2341066
PF02341066
PF2341066
Xalkori - Narrower
Concept UI M0578350
Preferred term Xalkori



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