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Descriptor English: Loperamide
Descriptor Spanish: Loperamida
Descriptor loperamida
Scope note: ANTIDIARREICO sintético de acción prolongada, que tiene escasa absorción a nivel intestinal y carece de efectos sobre el sistema adrenergico o el sistema nervioso central, aunque puede actuar como antagonista de la histamina e interferir con la acetilcolina liberada localmente.
Descriptor Portuguese: Loperamida
Descriptor French: Lopéramide
Entry term(s): Hydrochloride, Loperamide
Imodium
Loperamide Hydrochloride
Loperamide Monohydrochloride
Monohydrochloride, Loperamide
R 18553
R-18553
R18553
Tree number(s): D03.383.621.440
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008139
Scope note: One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antidiarrheals
Registry Number: 6X9OC3H4II
CAS Type 1 Name: 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-
Previous Indexing: Amides (1974-1975)
Chlorobenzenes (1974-1975)
Piperidines (1974-1975)
Public MeSH Note: 91; was see under PIPERIDINES 1976-90
History Note: 91(76); was see under PIPERIDINES 1976-90
DeCS ID: 8314
Unique ID: D008139
NLM Classification: QV 71
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1975/07/23
Revision Date: 2016/05/31
Loperamide - Preferred
Concept UI M0012692
Scope note One of the long-acting synthetic ANTIDIARRHEALS; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Preferred term Loperamide
R-18553 - Narrower
Concept UI M0012693
Preferred term R-18553
Entry term(s) R 18553
R18553
Imodium - Narrower
Concept UI M0012695
Preferred term Imodium
Loperamide Hydrochloride - Narrower
Concept UI M0330089
Preferred term Loperamide Hydrochloride
Entry term(s) Hydrochloride, Loperamide
Loperamide Monohydrochloride
Monohydrochloride, Loperamide



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