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Descriptor English: von Willebrand Factor
Descriptor Spanish: Factor de von Willebrand
Descriptor factor de von Willebrand
Entry term(s) antígeno relacionado con el factor VIII
Scope note: Proteína plasmática de gran peso molecular producida por las células endoteliales y los megacariocitos y que es parte del complejo factor VIII/factor de von Willebrand. El factor de von Willebrand tiene receptores para el colágeno, plaquetas y actividad ristocetínica así como los determinantes antigénicos inmunológicamente distintos. Funciona en la adherencia de las plaquetas al colágeno y en la formación del tapón hemostático. El tiempo de hemorragia prolongado en la enfermedad de von Willebrand se debe a la deficiencia en este factor.
Descriptor Portuguese: Fator de von Willebrand
Descriptor French: Facteur de von Willebrand
Entry term(s): Factor VIII Related Antigen
Factor VIII-Related Antigen
Factor VIIIR Ag
Factor VIIIR RCo
Factor VIIIR-Ag
Factor VIIIR-RCo
Plasma Factor VIII Complex
Ristocetin Cofactor
Ristocetin Willebrand Factor
Ristocetin-Willebrand Factor
von Willebrand Protein
Tree number(s): D12.776.124.125.920
D23.119.985
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014841
Scope note: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Annotation: / defic = VON WILLEBRAND DISEASE or specific type of Von Willebrand Disease
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Blood Coagulation Factors (1966-1974)
Blood Platelets (1966-1974)
von Willebrand's Disease (1966-1975)
Public MeSH Note: 86; was see under BLOOD COAGULATION FACTORS 1976-85
Online Note: use FACTOR VIII & ANTIGENS to search FACTOR VIII RELATED ANTIGEN 1977-89
History Note: 86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89
Entry Version: VWF
Related: Coagulants MeSH
Weibel-Palade Bodies MeSH
von Willebrand Disease, Type 1 MeSH
von Willebrand Disease, Type 2 MeSH
von Willebrand Disease, Type 3 MeSH
von Willebrand Diseases MeSH
DeCS ID: 22305
Unique ID: D014841
NLM Classification: WH 310
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1975/07/25
Revision Date: 2009/07/06
von Willebrand Factor - Preferred
Concept UI M0022850
Scope note A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Preferred term von Willebrand Factor
Entry term(s) Factor VIII Related Antigen
Factor VIII-Related Antigen
Factor VIIIR Ag
Factor VIIIR RCo
Factor VIIIR-Ag
Factor VIIIR-RCo
Ristocetin Cofactor
Ristocetin Willebrand Factor
Ristocetin-Willebrand Factor
von Willebrand Protein
Plasma Factor VIII Complex - Broader
Concept UI M0022849
Preferred term Plasma Factor VIII Complex



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