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Descriptor in English: Prothrombin
Descriptor in Spanish: Protrombina
Descriptor in Portuguese: Protrombina
Descriptor in French: Prothrombine
Entry term(s): Blood Coagulation Factor II
Coagulation Factor II
Differentiation Reversal Factor
Factor II
Factor II, Coagulation
Factor, Differentiation Reversal
II, Coagulation Factor
Tree number(s): D08.622.709
D12.776.124.125.800
D12.776.811.243.709
D23.119.945
Scope note: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Annotation: a blood coag factor; an enzyme precursor
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
See also the descriptors: Coagulants MeSH
DeCS UI: 22270
Descriptor UI: D011516
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30
Prothrombin - Preferred
Concept UI M0017904
Scope note A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Preferred term Prothrombin
Entry term(s) Blood Coagulation Factor II
Coagulation Factor II
Differentiation Reversal Factor
Factor II
Factor II, Coagulation
Factor, Differentiation Reversal
II, Coagulation Factor



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