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Descriptor English: Factor XII
Descriptor Spanish: Factor XII
Descriptor Portuguese: Fator XII
Descriptor French: Facteur XII
Entry term(s): Coagulation Factor XII
Factor 12
Factor Twelve
Hageman Factor
Tree number(s): D08.622.500
D12.776.124.125.450
D12.776.811.243.500
D23.119.450
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005174
Scope note: Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Factor XII Deficiency
Registry Number: 9001-30-3
CAS Type 1 Name: Blood-coagulation factor XII
Public MeSH Note: 66
History Note: 66(64)
Related: Coagulants MeSH
Hereditary Angioedema Type III MeSH
DeCS ID: 22175
Unique ID: D005174
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/02/24
Factor XII - Preferred
Concept UI M0008158
Scope note Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Preferred term Factor XII
Entry term(s) Coagulation Factor XII
Factor 12
Factor Twelve
Hageman Factor



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