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Descriptor English: Tissue Plasminogen Activator
Descriptor Spanish: Activador de Tejido Plasminógeno
Descriptor Portuguese: Ativador de Plasminogênio Tecidual
Descriptor French: Activateur tissulaire du plasminogène
Entry term(s): Actilyse
Activase
Alteplase
Lysatec rt PA
Lysatec rt-PA
Lysatec rtPA
Plasminogen Activator, Tissue
Plasminogen Activator, Tissue Type
Plasminogen Activator, Tissue-Type
T Plasminogen Activator
T-Plasminogen Activator
TTPA
Tisokinase
Tissue Activator D 44
Tissue Activator D-44
Tissue Type Plasminogen Activator
Tissue-Type Plasminogen Activator
Tree number(s): D08.811.277.656.300.760.875
D08.811.277.656.959.350.875
D12.776.124.125.662.768
D23.119.970
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010959
Scope note: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Fibrinolytic Agents
Registry Number: EC 3.4.21.68
Previous Indexing: Enzyme Activation (1974-1975)
Peptide Hydrolases (1975)
Plasminogen Activators (1976-1985)
Public MeSH Note: 98; see ALTEPLASE 1992-97; see PLASMINOGEN ACTIVATOR, TISSUE-TYPE 1986-91
History Note: 98(86)
DeCS ID: 30438
Unique ID: D010959
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1985/06/12
Revision Date: 2016/07/01
Tissue Plasminogen Activator - Preferred
Concept UI M0016991
Scope note A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Preferred term Tissue Plasminogen Activator
Entry term(s) Alteplase
Plasminogen Activator, Tissue
Plasminogen Activator, Tissue Type
Plasminogen Activator, Tissue-Type
T Plasminogen Activator
T-Plasminogen Activator
TTPA
Tisokinase
Tissue Activator D 44
Tissue Activator D-44
Tissue Type Plasminogen Activator
Tissue-Type Plasminogen Activator
Activase - Narrower
Concept UI M0333862
Preferred term Activase
Actilyse - Narrower
Concept UI M0016992
Preferred term Actilyse
Entry term(s) Lysatec rt PA
Lysatec rt-PA
Lysatec rtPA



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