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Descriptor English: Myosins
Descriptor Spanish: Miosinas
Descriptor miosinas
Entry term(s) ATPasa de miosina
Scope note: Superfamilia diversa de proteínas que actúan como proteínas de traslado. Comparten características comunes de capacidad de unión a las ACTINAS y de hidrólisis de MgATP. Las miosinas están formadas en general por cadenas pesadas que intervienen en la locomoción y cadenas ligeras que actúan en la regulación. En la estructura de la cadena pesada de la miosina existen tres dominios: la cabeza, el cuello y la cola. La región de la cabeza de la cadena pesada contiene el dominio de unión a la actina y el dominio MgATPasa, que proporciona energía para la locomoción; la región del cuello interviene en la unión de las cadenas ligeras; y la región de la cola proporciona un punto de anclaje que mantiene la posición de la cadena pesada. La superfamilia de las miosinas se organiza en clases estructurales conforme al tipo de las subunidades que contienen y a su disposición.
Descriptor Portuguese: Miosinas
Descriptor French: Myosines
Entry term(s): Actomyosine ATPase
Actomyosine adénosine triphosphatase
Myosine ATPase
Myosine adénosine triphosphatase
Tree number(s): D05.750.078.730.475
D08.811.277.040.025.193.750
D12.776.210.500.600
D12.776.220.525.475
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009218
Scope note: A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.
Annotation: general or unspecified; prefer specifics
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 3.6.4.1
DeCS ID: 29449
Unique ID: D009218
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/09
Myosines - Preferred
Concept UI M0014361
Preferred term Myosines
Entry term(s) Myosine ATPase
Myosine adénosine triphosphatase
Actomyosine adénosine triphosphatase - Related but not broader or narrower
Concept UI M0375356
Preferred term Actomyosine adénosine triphosphatase
Entry term(s) Actomyosine ATPase



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