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Descriptor English: CD40 Antigens
Descriptor Spanish: Antígenos CD40
Descriptor antígenos CD40
Entry term(s) antígeno CD40
antígeno CDw40
miembro 5 de la superfamilia de receptores de factores de necrosis tumoral
receptor TNFRSF5
Scope note: Miembro de la superfamilia de receptores de factores de necrosis tumoral, con especificidad para el LIGANDO CD40. Se encuentra en los LINFOCITOS B maduros y en algunas CÉLULAS EPITELIALES, CÉLULAS DENDRÍTICAS linfoides. La evidencia sugiere que la activación de células-B dependiente del CD40 es importante para generar memoria en las células-B en los centros germinales. Las mutaciones en el gen del antígeno CD40 se traduce en un SÍNDROME DE INMUNODEFICIENCIA DE HIPER-IGM DE TIPO 3. La señalizacion del receptor se produce cuando se une a FACTORES ASOCIADOS A RECEPTORES DE TNF.
Descriptor Portuguese: Antígenos CD40
Descriptor French: Antigènes CD40
Entry term(s): Antigen, CD40
Antigen, CDw40
Antigens, CD40
CD40 Antigen
CDw40 Antigen
Receptor, TNFRSF5
TNFRSF5 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 5
Tree number(s): D12.776.465.750
D12.776.543.750.705.852.760.097
D23.050.301.264.051.140
D23.101.100.150.140
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019013
Scope note: Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Antigens, CD (1990-1995)
Antigens, Differentiation, B-Lymphocyte (1988-1995)
Public MeSH Note: 2018; see ANTIGENS, CD40 1996-2017, CD40 ANTIGEN 1989-95, and CDW40 ANTIGEN 1988-95; CD40 ANTIGEN was indexed under ANTIGENS, CD 1990-95; and under ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE 1989-95; CDW40 ANTIGEN was indexed under ANTIGENS, CD 1990-95; and under ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE 1988-95
History Note: 2018 (1988)
Related: CD40 Ligand MeSH
DeCS ID: 32846
Unique ID: D019013
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2017/05/24
CD40 Antigens - Preferred
Concept UI M0028391
Scope note Members of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations in the CD40 antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Preferred term CD40 Antigens
Entry term(s) Antigen, CD40
Antigen, CDw40
Antigens, CD40
CD40 Antigen
CDw40 Antigen
Receptor, TNFRSF5
TNFRSF5 Receptor
Tumor Necrosis Factor Receptor Superfamily, Member 5



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