| Descriptor English: | Cytochrome P-450 CYP11B2 | ||||||
| Descriptor Spanish: |
Citocromo P-450 CYP11B2
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| Descriptor Portuguese: | Citocromo P-450 CYP11B2 | ||||||
| Descriptor French: | Cytochrome P-450 CYP11B2 | ||||||
| Entry term(s): |
18-hydroxylase, Corticosterone 18-monooxygenase, Corticosterone Aldosterone Synthase Aldosterone Synthase Cytochrome P-450 Aldosynthase CYP 11B2 CYP11B2 Corticosterone 18 hydroxylase Corticosterone 18 monooxygenase Corticosterone 18-hydroxylase Corticosterone 18-monooxygenase Cytochrome P 450 CYP11B2 Cytochrome P 450c11AS Cytochrome P-450c11AS Cytochrome P450 11B2 Cytochrome P450Aldo P450c11AS Steroid 18 Hydroxylase Steroid 18-Hydroxylase |
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| Tree number(s): |
D08.244.453.484.500 D08.244.453.915.050 D08.811.682.690.708.170.425.500 D08.811.682.690.708.170.915.050 D12.776.422.220.453.484.500 D12.776.422.220.453.915.050 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019405 | ||||||
| Scope note: | A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE. |
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| Annotation: | /antag: coordinate with CYTOCHROME P-450 ENZYME INHIBITORS |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 1.14.15.4 | ||||||
| Previous Indexing: |
Cytochrome P-450 (1984-1996) Desoxycorticosterone (1979-1982) Steroid 11 beta-Monooxygenase (1994-1996) Steroid Hydroxylases (1979-1993) |
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| Public MeSH Note: | 2015; see ALDOSTERONE SYNTHASE 2003-2014; see CYTOCHROME P-450 CYP11B2 1977-2002; for STEROID 18-HYDROXYLASE see CYTOCHROME P-450 1984-1996, see STEROID 11-HYDROXYLASE 1994-1996, see STEROID HYDROXYLASES 1979-1993, & see DESOXYCORTICOSTERONE 1979-1982 |
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| History Note: | 2015 (1979) |
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| DeCS ID: | 33013 | ||||||
| Unique ID: | D019405 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1997/01/01 | ||||||
| Date of Entry: | 1996/06/24 | ||||||
| Revision Date: | 2020/06/22 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Cytochrome P-450 CYP11B2
- Preferred
Corticosterone 18-monooxygenase
- Related but not broader or narrower
| Concept UI |
M0028872 |
| Scope note | A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE. |
| Preferred term | Cytochrome P-450 CYP11B2 |
| Entry term(s) |
Aldosterone Synthase Aldosterone Synthase Cytochrome P-450 Aldosynthase CYP 11B2 CYP11B2 Cytochrome P 450 CYP11B2 Cytochrome P 450c11AS Cytochrome P-450c11AS Cytochrome P450 11B2 Cytochrome P450Aldo P450c11AS Steroid 18 Hydroxylase Steroid 18-Hydroxylase |
| Concept UI |
M0072975 |
| Preferred term | Corticosterone 18-monooxygenase |
| Entry term(s) |
18-hydroxylase, Corticosterone 18-monooxygenase, Corticosterone Corticosterone 18 hydroxylase Corticosterone 18 monooxygenase Corticosterone 18-hydroxylase |
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