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Descriptor English: Aromatase
Descriptor Spanish: Aromatasa
Descriptor aromatasa
Entry term(s) CYP19
citocromo P-450 CYP19
citocromo P-450(AROM)
Scope note: Enzima que cataliza la desaturación (aromatización) del anillo A de los andrógenos C19 y los convierte en estrógenos C18. En este proceso se elimina 19-metilo. Esta enzima está unida a la membrana, localizada en el retículo endoplasmático de las células productoras de estrógenos de los ovarios, la placenta, los testículos, el tejido adiposo y el cerebral. El gen CYP19 codifica la aromatasa, y funciona formando un complejo con la NADPH-FERRIHEMOPROTEÍNA REDUCTASA en el sistema del citocromo P-450.
Descriptor Portuguese: Aromatase
Descriptor French: Aromatase
Entry term(s): Androstenedione Aromatase
Aromatase, Androstenedione
CYP 19
CYP19
CYP19 Protein
Cytochrome P 450 CYP19
Cytochrome P-450 CYP19
Cytochrome P-450(AROM)
Cytochrome P450 19
Estrogen Synthase
Estrogen Synthetase
P450AROM
Protein, CYP19
Tree number(s): D08.244.453.489.500
D08.244.453.915.099
D08.811.682.690.708.170.447.500
D08.811.682.690.708.170.915.099
D12.776.422.220.453.489.500
D12.776.422.220.453.915.099
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001141
Scope note: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Aromatase Inhibitors
Registry Number: EC 1.14.14.1
Previous Indexing: Androstanes (1972-1974)
Estrogens (1972-1974)
Oxidoreductases (1972-1974)
Public MeSH Note: 86; was see under OXIDOREDUCTASES 1975-85
History Note: 86(75); was see under OXIDOREDUCTASES 1975-85
DeCS ID: 23161
Unique ID: D001141
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/05/27
Aromatase - Preferred
Concept UI M0001707
Scope note An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.
Preferred term Aromatase
Entry term(s) Androstenedione Aromatase
Aromatase, Androstenedione
CYP 19
CYP19
CYP19 Protein
Cytochrome P 450 CYP19
Cytochrome P-450 CYP19
Cytochrome P-450(AROM)
Cytochrome P450 19
Estrogen Synthase
Estrogen Synthetase
P450AROM
Protein, CYP19



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