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Descriptor English: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Descriptor Spanish: 25-Hidroxivitamina D3 1-alfa-Hidroxilasa
Descriptor 25-hidroxivitamina D3 1-alfa-hidroxilasa
Entry term(s) 25-hidroxicolecalciferol 1-hidroxilasa
CYP27B1
CYP27B1 del citocromo P-450
calcidiol 1-monooxigenasa
Scope note: Enzima del citocromo P450 mitocondrial que cataliza la 1-alfa-hidroxilación de la 25-hidroxivitamina D3 (también conocida como 25-hidroxicolecalciferol) en presencia de oxígeno molecular y de NADPH-FERRIHEMOPROTEÍNA REDUCTASA. Esta enzima, codificada por el gen CYP27B1, convierte la 25-hidroxivitamina D3 en 1-alfa,25-dihidroxivitamina D3, que es la forma activa de la VITAMINA D en la regulación del crecimiento óseo y del metabolismo del calcio. Esta enzima también actúa sobre la 25-hidroxivitamina D2 (ergocalciferol) de plantas.
Descriptor Portuguese: 25-Hidroxivitamina D3 1-alfa-Hidroxilase
Descriptor French: 25-Hydroxyvitamine D3 1-alpha-hydroxylase
Entry term(s): 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
1-alpha-Hydroxylase, 25-Hydroxyvitamin D
1-hydroxylase, 25-Hydroxyvitamin D2
25 Hydroxycholecalciferol 1 Hydroxylase
25 Hydroxyergocalciferol 1 alpha Hydroxylase
25 Hydroxyvitamin D 1 alpha Hydroxylase
25 Hydroxyvitamin D2 1 hydroxylase
25 Hydroxyvitamin D3 1 alpha Hydroxylase
25-Hydroxycholecalciferol 1-Hydroxylase
25-Hydroxycholecalciferol-1-Hydroxylase
25-Hydroxyergocalciferol 1-alpha-Hydroxylase
25-Hydroxyvitamin D 1-alpha-Hydroxylase
25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
25-Hydroxyvitamin D2 1-hydroxylase
CYP27B1
Calcidiol 1 Monooxygenase
Calcidiol 1-Monooxygenase
Cytochrome P 450 CYP27B1
Cytochrome P-450 CYP27B1
Tree number(s): D08.244.453.499.500
D08.244.453.915.400
D08.811.682.690.708.170.493.500
D08.811.682.690.708.170.915.400
D12.776.422.220.453.499.500
D12.776.422.220.453.915.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015090
Scope note: A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.13.13
CAS Type 1 Name: Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
Previous Indexing: Hydroxycholecalciferols (1973-1974)
Steroid Hydroxylases (1973-1974)
Public MeSH Note: 2003; see 25-HYDROXYCHOLECALCIFEROL 1-HYDROXYLASE 1991-2002, see STEROID HYDROXYLASES 1975-1990; 25-HYDROXYVITAMIN D2 1-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1976-2002
History Note: 2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002
DeCS ID: 7046
Unique ID: D015090
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/06/03
25-Hydroxyvitamin D3 1-alpha-Hydroxylase - Preferred
Concept UI M0023210
Scope note A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
Preferred term 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Entry term(s) 1-alpha-Hydroxylase, 25-Hydroxyergocalciferol
1-alpha-Hydroxylase, 25-Hydroxyvitamin D
1-hydroxylase, 25-Hydroxyvitamin D2
25 Hydroxycholecalciferol 1 Hydroxylase
25 Hydroxyergocalciferol 1 alpha Hydroxylase
25 Hydroxyvitamin D 1 alpha Hydroxylase
25 Hydroxyvitamin D2 1 hydroxylase
25 Hydroxyvitamin D3 1 alpha Hydroxylase
25-Hydroxycholecalciferol 1-Hydroxylase
25-Hydroxycholecalciferol-1-Hydroxylase
25-Hydroxyergocalciferol 1-alpha-Hydroxylase
25-Hydroxyvitamin D 1-alpha-Hydroxylase
25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
25-Hydroxyvitamin D2 1-hydroxylase
CYP27B1
Calcidiol 1 Monooxygenase
Calcidiol 1-Monooxygenase
Cytochrome P 450 CYP27B1
Cytochrome P-450 CYP27B1



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