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Descriptor English: Steroid 17-alpha-Hydroxylase
Descriptor Spanish: Esteroide 17-alfa-Hidroxilasa
Descriptor esteroide 17-alfa-hidroxilasa
Entry term(s) 17 alfa-hidroxilasa
17,20-liasa
CYP17
P450(c17)
citocromo P-450 (17 alfa)
esteroide 17 alfa-monooxigenasa
esteroide 17-hidroxilasa
esteroide 17-monooxigenasa
Scope note: Enzima del citocromo P450 de los microsomas que cataliza la 17-alfa-hidroxilación de la progesterona o la pregnenolona y la posterior escisión de los dos carbonos residuales en C17 en presencia de oxígeno molecular y NADPH-FERRIHEMOPROTEÍNA REDUCTASA. Esta enzima, codificada por el gen CYP17, produce precursores para la síntesis de glucocorticoides, andrógenos y estrógenos. Los defectos del gen CYP17 dan lugar a la HIPERPLASIA SUPRARRENAL CONGÉNITA y a una diferenciación sexual anormal.
Descriptor Portuguese: Esteroide 17-alfa-Hidroxilase
Descriptor French: Steroid 17-alpha-hydroxylase
Entry term(s): 17 alpha Hydroxylase
17 alpha Hydroxylase Cytochrome P 450
17 alpha Hydroxyprogesterone Aldolase
17 alpha-Hydroxylase
17 alpha-Hydroxylase Cytochrome P-450
17 alpha-Hydroxylase, Steroid
17 alpha-Hydroxyprogesterone Aldolase
17 alpha-Monooxygenase, Steroid
17,20 Desmolase
17,20 Lyase
17,20-Desmolase
17,20-Lyase
17-Hydroxylase, Steroid
17-Monooxygenase, Steroid
17-alpha-Hydroxylase, Steroid
Aldolase, 17 alpha-Hydroxyprogesterone
Aldolase, Hydroxyprogesterone
CYP17
Cytochrome P-450(17 alpha)
Cytochrome P-450(17-alpha)
Cytochrome P450(17 alpha)
Hydroxyprogesterone Aldolase
P450(c17)
Steroid 17 Hydroxylase
Steroid 17 Monooxygenase
Steroid 17 alpha Hydroxylase
Steroid 17 alpha Monooxygenase
Steroid 17 alpha-Hydroxylase
Steroid 17 alpha-Monooxygenase
Steroid 17-Hydroxylase
Steroid 17-Monooxygenase
Steroid-17-Hydroxylase
alpha-Hydroxyprogesterone Aldolase, 17
alpha-Monooxygenase, Steroid 17
Tree number(s): D08.244.453.487.500
D08.244.453.915.748
D08.811.682.690.708.170.444.500
D08.811.682.690.708.170.915.748
D12.776.422.220.453.487.500
D12.776.422.220.453.915.748
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013254
Scope note: A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Adrenal Hyperplasia, Congenital
Registry Number: EC 1.14.14.19
CAS Type 1 Name: Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)
Previous Indexing: Steroid Hydroxylases (1973-1977)
Public MeSH Note: 2003; see STEROID 17 ALPHA-MONOOXYGENASE 1997-2002, see STEROID 17-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990; for STEROID-17-HYDROXYLASE see STEROID HYDROXYLASES 1978-1989; for 17,20-LYASE see 17 ALPHA-HYDROXYPROGESTERONE ALDOLASE 1996-1997
History Note: 2003 (1978)
Related: Adrenal Hyperplasia, Congenital MeSH
DeCS ID: 23464
Unique ID: D013254
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2016/06/01
Steroid 17-alpha-Hydroxylase - Preferred
Concept UI M0020523
Scope note A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
Preferred term Steroid 17-alpha-Hydroxylase
Entry term(s) 17 alpha Hydroxylase
17 alpha Hydroxylase Cytochrome P 450
17 alpha-Hydroxylase
17 alpha-Hydroxylase Cytochrome P-450
17 alpha-Hydroxylase, Steroid
17 alpha-Monooxygenase, Steroid
17,20 Desmolase
17,20 Lyase
17,20-Desmolase
17,20-Lyase
17-Hydroxylase, Steroid
17-Monooxygenase, Steroid
17-alpha-Hydroxylase, Steroid
CYP17
Cytochrome P-450(17 alpha)
Cytochrome P-450(17-alpha)
Cytochrome P450(17 alpha)
P450(c17)
Steroid 17 Hydroxylase
Steroid 17 Monooxygenase
Steroid 17 alpha Hydroxylase
Steroid 17 alpha Monooxygenase
Steroid 17 alpha-Hydroxylase
Steroid 17 alpha-Monooxygenase
Steroid 17-Hydroxylase
Steroid 17-Monooxygenase
Steroid-17-Hydroxylase
alpha-Monooxygenase, Steroid 17
17 alpha-Hydroxyprogesterone Aldolase - Narrower
Concept UI M0028873
Preferred term 17 alpha-Hydroxyprogesterone Aldolase
Entry term(s) 17 alpha Hydroxyprogesterone Aldolase
Aldolase, 17 alpha-Hydroxyprogesterone
Aldolase, Hydroxyprogesterone
Hydroxyprogesterone Aldolase
alpha-Hydroxyprogesterone Aldolase, 17



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