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Descriptor English: Steroid 12-alpha-Hydroxylase
Descriptor Spanish: Esteroide 12-alfa-Hidroxilasa
Descriptor esteroide 12-alfa-hidroxilasa
Entry term(s) 12-alfa-hidroxilasa
esteroide 12-monooxigenasa
esterol 12-alfa-hidroxilasa
Scope note: Enzima del citocromo P450 de los microsomas hepáticos que cataliza la 12-alfa-hidroxilación de una amplia gama de esteroles en presencia de oxígeno molecular y NADPH-FERRIHEMOPROTEÍNA REDUCTASA. Esta enzima, codificada por el gen CYP8B1, convierte la 7-alfa-hidroxi-4-colesten-3-ona en 7-alfa-12-alfa-dihidroxi-4-colesten-3-ona y es necesaria en la síntesis de ÁCIDOS BILIARES a partir del colesterol.
Descriptor Portuguese: Esteroide 12-alfa-Hidroxilase
Descriptor French: Steroid 12-alpha-hydroxylase
Entry term(s): 12 alpha Hydroxylase
12 alpha-Hydroxylase, Sterol
12-alpha-Hydroxylase
12alpha Hydroxylase
12alpha-Hydroxylase
CYP8B1
Cytochrome P450 8B1
Cytochrome P450 CYP8B1
Steroid 12 Hydroxylase
Steroid 12 Monooxygenase
Steroid 12 alpha Hydroxylase
Steroid 12-Hydroxylase
Steroid 12-Monooxygenase
Steroid-12-Hydroxylase
Steroid-12-Monooxygenase
Sterol 12 alpha Hydroxylase
Sterol 12 alpha-Hydroxylase
Sterol 12-alpha-Hydroxylase
alpha-Hydroxylase, Sterol 12
Tree number(s): D08.244.453.900.500
D08.244.453.915.730
D08.811.682.690.708.170.900.500
D08.811.682.690.708.170.915.730
D12.776.422.220.453.900.500
D12.776.422.220.453.915.730
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013253
Scope note: A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.18.8
CAS Type 1 Name: Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)
Previous Indexing: Steroid Hydroxylases (1973-1977)
Public MeSH Note: 2003; see STEROID 12-MONOOXYGENASE 1997-2002, see STEROID 12-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1978-1990; for STEROID 12-MONOOXYGENASE see STEROID 12-HYDROXYLASE 1978-1996
History Note: 2003 (1978)
DeCS ID: 29288
Unique ID: D013253
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2016/06/28
Steroid 12-alpha-Hydroxylase - Preferred
Concept UI M0020522
Scope note A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
Preferred term Steroid 12-alpha-Hydroxylase
Entry term(s) 12 alpha Hydroxylase
12 alpha-Hydroxylase, Sterol
12-alpha-Hydroxylase
12alpha Hydroxylase
12alpha-Hydroxylase
CYP8B1
Cytochrome P450 8B1
Cytochrome P450 CYP8B1
Steroid 12 Hydroxylase
Steroid 12 Monooxygenase
Steroid 12 alpha Hydroxylase
Steroid 12-Hydroxylase
Steroid 12-Monooxygenase
Steroid-12-Hydroxylase
Steroid-12-Monooxygenase
Sterol 12 alpha Hydroxylase
Sterol 12 alpha-Hydroxylase
Sterol 12-alpha-Hydroxylase
alpha-Hydroxylase, Sterol 12



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