| Descriptor English: | Steroid 21-Hydroxylase | ||||||
| Descriptor Spanish: |
Esteroide 21-Hidroxilasa
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| Descriptor Portuguese: | Esteroide 21-Hidroxilase | ||||||
| Descriptor French: | Steroid 21-hydroxylase | ||||||
| Entry term(s): |
21 Hydroxylase 21-Hydroxylase Cytochrome P 450 21 Hydroxylase Cytochrome P 450 CYP21 Cytochrome P 450 c21 Cytochrome P-450 21-Hydroxylase Cytochrome P-450 CYP21 Cytochrome P-450 c21 Cytochrome P-450(c-21) Cytochrome P450c21 P-450 c21, Cytochrome Progesterone 21 Hydroxylase Progesterone 21-Hydroxylase Steroid 21 Hydroxylase Steroid 21 Monooxygenase Steroid 21-Monooxygenase Steroid-21-Hydroxylase |
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| Tree number(s): |
D08.244.453.493.500 D08.244.453.915.760 D08.811.682.690.708.170.463.500 D08.811.682.690.708.170.915.760 D12.776.422.220.453.493.500 D12.776.422.220.453.915.760 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D013255 | ||||||
| Scope note: | An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL). |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Entry Combination: |
deficiency:Adrenal Hyperplasia, Congenital
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| Registry Number: | EC 1.14.14.16 | ||||||
| CAS Type 1 Name: | Steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating) | ||||||
| Previous Indexing: |
Steroid Hydroxylases (1973-1977) |
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| Public MeSH Note: | 2003; see STE see STEROID 21-MONOOXYGENASE 1997-2002, see STEROID 21-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1978-1990; for STEROID 21-MONOOXYGENASE see STEROID 21-HYDROXYLASE 1978-1996; CYTOCHROME P-450 C21 was indexed under STEROID 21-HYDROXYLASE 2004 & under CYTOCHROME P-450 ENZYME SYSTEM 1996-2003 |
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| History Note: | 2003 (1978) |
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| DeCS ID: | 23465 | ||||||
| Unique ID: | D013255 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1977/04/15 | ||||||
| Revision Date: | 2016/06/01 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Steroid 21-Hydroxylase
- Preferred
| Concept UI |
M0020524 |
| Scope note | An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL). |
| Preferred term | Steroid 21-Hydroxylase |
| Entry term(s) |
21 Hydroxylase 21-Hydroxylase Cytochrome P 450 21 Hydroxylase Cytochrome P 450 CYP21 Cytochrome P 450 c21 Cytochrome P-450 21-Hydroxylase Cytochrome P-450 CYP21 Cytochrome P-450 c21 Cytochrome P-450(c-21) Cytochrome P450c21 P-450 c21, Cytochrome Progesterone 21 Hydroxylase Progesterone 21-Hydroxylase Steroid 21 Hydroxylase Steroid 21 Monooxygenase Steroid 21-Monooxygenase Steroid-21-Hydroxylase |
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