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Descriptor English: Cholesterol 7-alpha-Hydroxylase
Descriptor Spanish: Colesterol 7-alfa-Hidroxilasa
Descriptor colesterol 7-alfa-hidroxilasa
Entry term(s) CYP7
CYP7A
citocromo P-450 CYP7
colesterol 7-alfa-monooxigenasa
Scope note: Enzima del citocromo P450 unida a la membrana que cataliza la 7-alfa-hidroxilación del COLESTEROL en presencia de oxígeno molecular y NADPH-FERRIHEMOPROTEÍNA REDUCTASA. Esta enzima, codificada por CYP7, convierte el colesterol en 7-alfa-hidroxicolesterol, que es el paso primero y limitante de la síntesis de los ÁCIDOS Y SALES BILIARES.
Descriptor Portuguese: Colesterol 7-alfa-Hidroxilase
Descriptor French: Cholesterol 7-alpha-hydroxylase
Entry term(s): CYP 7
CYP 7A
CYP7
CYP7A
Cholesterol 7 Hydroxylase
Cholesterol 7 alpha Hydroxylase
Cholesterol 7 alpha Monooxygenase
Cholesterol 7-alpha-Monooxygenase
Cholesterol 7alpha Hydroxylase
Cholesterol 7alpha-Hydroxylase
Cholesterol-7-Hydroxylase
Cytochrome P 450 CYP7
Cytochrome P-450 CYP7
Cytochrome P450 7
Tree number(s): D08.244.453.890.500
D08.244.453.915.200
D08.811.682.690.708.170.890.500
D08.811.682.690.708.170.915.200
D12.776.422.220.453.890.500
D12.776.422.220.453.915.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002790
Scope note: A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.14.14.23
CAS Type 1 Name: Cholesterol,NADPH:oxygen oxidoreductase (7 alpha-hydroxylating)
Previous Indexing: Cholesterol (1974)
Steroid Hydroxylases (1974)
Public MeSH Note: 2003; see CHOLESTEROL 7 ALPHA-MONOOXYGENASE 1997-2002, see CHOLESTEROL-7-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1975-1990
History Note: 2003 (1975)
DeCS ID: 23193
Unique ID: D002790
NLM Classification: QU 140
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2016/06/01
Cholesterol 7-alpha-Hydroxylase - Preferred
Concept UI M0004276
Scope note A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
Preferred term Cholesterol 7-alpha-Hydroxylase
Entry term(s) CYP 7
CYP 7A
CYP7
CYP7A
Cholesterol 7 Hydroxylase
Cholesterol 7 alpha Hydroxylase
Cholesterol 7 alpha Monooxygenase
Cholesterol 7-alpha-Monooxygenase
Cholesterol 7alpha Hydroxylase
Cholesterol 7alpha-Hydroxylase
Cholesterol-7-Hydroxylase
Cytochrome P 450 CYP7
Cytochrome P-450 CYP7
Cytochrome P450 7



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