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Descriptor English: Steroid 11-beta-Hydroxylase
Descriptor Spanish: Esteroide 11-beta-Hidroxilasa
Descriptor esteroide 11-beta-hidroxilasa
Entry term(s) CYP11B1
citocromo P-450 (11 beta)
esteroide 11-beta-monooxigenasa
Scope note: Enzima del citocromo P450 mitocondrial que cataliza la hidroxilación 11-beta de los esteroides en presencia de oxigeno molecular y de NADPH-FERRIHEMOPROTEÍNA REDUCTASA. Esta enzima, codificada por el gen CYP11B1, es importante en la síntesis de la CORTICOSTERONA y de HIDROCORTISONA. Los defectos de CYP11B1 causan HIPERPLASIA SUPRARRENAL CONGÉNITA.
Descriptor Portuguese: Esteroide 11-beta-Hidroxilase
Descriptor French: Steroid 11-beta-hydroxylase
Entry term(s): 11 beta Hydroxylase
11 beta-Hydroxylase
CYP 11B1
CYP11B1
Cytochrome P 450 CYP11B1
Cytochrome P-450 CYP11B1
Cytochrome P-450(11 beta)
Cytochrome P450 11B1
Steroid 11 Hydroxylase
Steroid 11 beta Hydroxylase
Steroid 11 beta Monooxygenase
Steroid 11-Hydroxylase
Steroid 11-beta-Monooxygenase
Steroid-11-Hydroxylase
Tree number(s): D08.244.453.484.750
D08.244.453.915.750
D08.811.682.690.708.170.425.750
D08.811.682.690.708.170.915.750
D12.776.422.220.453.484.750
D12.776.422.220.453.915.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013252
Scope note: A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Adrenal Hyperplasia, Congenital
Registry Number: EC 1.14.15.4
CAS Type 1 Name: Steroid, reduced-adrenal-ferredoxin:oxygen oxidoreductase (11 beta-hydroxylating)
Previous Indexing: Steroid Hydroxylases (1973-1977)
Public MeSH Note: 2003; see STEROID 11 BETA-MONOOXYGENASE 1997-2002, see STEROID 11-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990, see STEROID-11-HYDROXYLASE 1978-1989
History Note: 2003 (1978)
Related: Adrenal Hyperplasia, Congenital MeSH
DeCS ID: 23463
Unique ID: D013252
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2016/05/27
Steroid 11-beta-Hydroxylase - Preferred
Concept UI M0020521
Scope note A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Preferred term Steroid 11-beta-Hydroxylase
Entry term(s) 11 beta Hydroxylase
11 beta-Hydroxylase
CYP 11B1
CYP11B1
Cytochrome P 450 CYP11B1
Cytochrome P-450 CYP11B1
Cytochrome P-450(11 beta)
Cytochrome P450 11B1
Steroid 11 Hydroxylase
Steroid 11 beta Hydroxylase
Steroid 11 beta Monooxygenase
Steroid 11-Hydroxylase
Steroid 11-beta-Monooxygenase
Steroid-11-Hydroxylase



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