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Descriptor English: Caspases
Descriptor Spanish: Caspasas
Descriptor caspasas
Entry term(s) caspasa
Scope note: Familia de CISTEÍNA ENDOPEPTIDASAS intracelulares que intervienen en la regulación de la INFLAMACIÓN y la APOPTOSIS. Específicamente escinden péptidos en un aminoácido CISTEÍNA que sigue a un residuo de ÁCIDO ASPÁRTICO. Las caspasas son activadas por escisión proteolítica de una forma precursora, dando lugar a las subunidades grande y pequeña que forman la enzima. Dado que el sitio de escisión de los precursores se corresponde con la especificidad de las caspasas, puede producirse la activación secuencial de los precursores por caspasas activadas.
Descriptor Portuguese: Caspases
Descriptor French: Caspases
Tree number(s): D08.811.277.656.262.500.126
D08.811.277.656.300.200.126
D12.776.476.075.405
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020169
Scope note: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Annotation: CASPASES, EFFECTOR and CASPASES, INITIATOR and specifics are available
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Caspase Inhibitors
Registry Number: EC 3.4.22.-
Related: Apoptose MeSH
DeCS ID: 33826
Unique ID: D020169
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1999/01/01
Date of Entry: 1998/06/10
Revision Date: 2020/05/27
Caspases - Preferred
Concept UI M0029891
Preferred term Caspases



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