| Descriptor English: | DCC Receptor | ||||||
| Descriptor Spanish: |
Receptor DCC
| ||||||
| Descriptor Portuguese: | Receptor DCC | ||||||
| Descriptor French: | Récepteur DCC | ||||||
| Entry term(s): |
DCC Netrin 1 Receptor DCC Tumor Suppressor Protein DCC-Netrin-1 Receptor Deleted in Colorectal Carcinoma Protein Receptor, DCC Receptor, DCC-Netrin-1 |
||||||
| Tree number(s): |
D12.644.360.075.413 D12.776.476.075.413 D12.776.543.750.003.500 D12.776.624.776.021 |
||||||
| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000075389 | ||||||
| Scope note: | A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells. |
||||||
| Allowable Qualifiers: |
AD administration & dosage AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CH chemistry CL classification DE drug effects DF deficiency GE genetics HI history IM immunology IP isolation & purification ME metabolism PH physiology RE radiation effects TU therapeutic use UL ultrastructure |
||||||
| Previous Indexing: |
Receptors, Cell Surface (2005-2017) Tumor Suppressor Proteins (2005-2017) |
||||||
| Public MeSH Note: | 2018 |
||||||
| History Note: | 2018 |
||||||
| DeCS ID: | 57057 | ||||||
| Unique ID: | D000075389 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/05/24 |
-
-
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
|
|
DCC Receptor
- Preferred
| Concept UI |
M000630298 |
| Scope note | A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells. |
| Preferred term | DCC Receptor |
| Entry term(s) |
DCC Netrin 1 Receptor DCC Tumor Suppressor Protein DCC-Netrin-1 Receptor Deleted in Colorectal Carcinoma Protein Receptor, DCC Receptor, DCC-Netrin-1 |
We want your feedback on the new DeCS / MeSH website
We invite you to complete a survey that will take no more than 3 minutes.
Go to survey
