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Descriptor English: Agouti Signaling Protein
Descriptor Spanish: Proteína de Señalización Agouti
Descriptor proteína de señalización Agouti
Scope note: Proteína segregada de aproximadamente 131 aminoácidos (según las especies) que regula la síntesis de los pigmentos de eumelanina (marrón/negra) de los MELANOCITOS. La proteína Agouti antagoniza la señalización de los RECEPTORES DE MELANOCORTINA y tiene una amplia distribución que incluye el TEJIDO ADIPOSO, GÓNADAS y CORAZÓN. Su hiperexpresión en los ratones Agouti da lugar a un color uniformemente amarillento, OBESIDAD y defectos metabólicos similares a los de la diabetes tipo II de los humanos.
Descriptor Portuguese: Proteína Agouti Sinalizadora
Descriptor French: Protéine de signalisation Agouti
Entry term(s): ASIP Protein
Agouti Protein
Agouti Switch Protein
Tree number(s): D12.644.276.049
D12.776.467.049
D23.529.049
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054366
Scope note: A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Intercellular Signaling Peptides and Proteins (1994-2007)
Public MeSH Note: 2008; AGOUTI PROTEIN was indexed under INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS 1993-2007
History Note: 2008 (1993)
DeCS ID: 52758
Unique ID: D054366
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Agouti Signaling Protein - Preferred
Concept UI M0214413
Scope note A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
Preferred term Agouti Signaling Protein
Entry term(s) ASIP Protein
Agouti Protein
Agouti Switch Protein



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