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Descriptor English: Midkine
Descriptor Spanish: Midkina
Descriptor midkina
Entry term(s) citocina MK
proteína asociada a la anfirregulina
Scope note: Factor de crecimiento de unión a la HEPARINA secretado y regulado por el desarrollo que es homólogo a la pleiotrofina (PTN). Regula la proliferación celular mediante su interacción con la CINASA DEL LINFOMA ANAPLÁSICO (ALK) e interviene en la formación de la NEOÍNTIMA después de una lesión arterial.
Descriptor Portuguese: Midkina
Descriptor French: Midkine
Entry term(s): Amphiregulin Associated Protein
Amphiregulin-Associated Protein
Cytokine MK
Tree number(s): D12.644.276.854
D12.776.467.848
D23.529.831
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000078792
Scope note: A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: 137497-38-2
Public MeSH Note: 2019; MIDKINE was indexed under CYTOKINES 2005-2018; and under CARRIER PROTEINS 1991-2004
History Note: 2019 (1991)
DeCS ID: 57860
Unique ID: D000078792
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/06/19
Midkine - Preferred
Concept UI M0187737
Scope note A developmentally regulated, HEPARIN-binding secreted growth factor homologous to pleiotrophin (PTN). It regulates cell proliferation through its interaction with ANAPLASTIC LYMPHOMA KINASE (ALK) and is involved in the formation of NEOINTIMA following arterial injury.
Preferred term Midkine
Entry term(s) Amphiregulin Associated Protein
Amphiregulin-Associated Protein
Cytokine MK



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