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Descriptor English: Apelin
Descriptor Spanish: Apelina
Descriptor apelina
Scope note: Ligando endógeno segregado, de 77 aminoácidos, para la proteína 1 similar al receptor de angiotensina II (RECEPTOR DE APELINA) que es escindido proteolíticamente en cuatro péptidos más pequeños: apelina-36, apelina-31, apelina-28 y apelina-13. Inhibe la entrada del VIH en las células que expresan tanto el APJ (receptor de apelina) como el ANTÍGENO CD4 y se expresa ampliamente en la mama lactante con la función de modular la respuesta inmunitaria neonatal.
Descriptor Portuguese: Apelina
Descriptor French: Apeline
Tree number(s): D12.644.276.150
D23.529.134
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000073861
Scope note: A 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Carrier Proteins (1998-2017)
Intercellular Signaling Peptides and Proteins (2006-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57049
Unique ID: D000073861
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/01
Apelin - Preferred
Concept UI M000624130
Scope note A 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.
Preferred term Apelin



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